苏黄止咳胶囊联合茶碱缓释片治疗哮喘急性发作患者的效果  

Effects of Suhuang Zhike capsules combined with Theophylline sustained-release tablets in treatment of patients with acute attack of asthma

作　　者：赖盈辉 陈骞 丁小相 LAI Yinghui;CHEN Qian;DING Xiaoxiang(Department of Respiratory Medicine of Ningdu County People’s Hospital,Ganzhou 342800 Jiangxi,China)

机构地区：[1]宁都县人民医院呼吸内科,江西赣州342800

出　　处：《中国民康医学》2024年第24期74-77,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察苏黄止咳胶囊联合茶碱缓释片治疗哮喘急性发作患者的效果。方法:选取2022年4月至2024年3月该院收治的78例哮喘急性发作患者进行前瞻性研究,按随机数字表法将其分为研究组与对照组各39例。对照组采用茶碱缓释片治疗,研究组在对照组基础上联合苏黄止咳胶囊治疗。比较两组临床症状消失时间,治疗前后气道重塑指标[转化生长因子-β1(TGF-β1)、细胞外信号调节蛋白激酶(ERK)、基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)]水平、疾病严重程度[哮喘控制测试(ACT)]评分、肺功能指标[第1秒用力呼吸容积(FEV_(1))、用力肺活量(FVC)]水平,以及不良反应发生率。结果:研究组胸部哮鸣音、气促、喘息、胸闷、咳嗽等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组TGF-β1、ERK、MMP-9、VEGF水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组ACT评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV_(1)、FVC水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苏黄止咳胶囊联合茶碱缓释片治疗哮喘急性发作患者可提高ACT评分和肺功能指标水平,缩短临床症状消失时间,以及降低气道重塑指标水平的效果优于单纯茶碱缓释片治疗。Objective:To observe effects of Suhuang Zhike capsules combined with Theophylline sustained-release tablets in treatment of patients with acute attack of asthma.Methods:A prospective study was conducted on 78 patients with acute attack of asthma admitted to this hospital from April 2022 to March 2024.According to the random number table method,they were divided into study group and control group,39 cases in each group.The control group was treated with Theophylline sustained-release tablets,while the study group was treated with Suhuang Zhike capsules on the basis of that of the control group.The disappearance time of clinical symptoms,the levels of airway remodeling indexes[transforming growth factor-β1(TGF-β1),extracellular signal-regulated protein kinase(ERK),matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF)],the disease severity[asthma control test(ACT)]score,the lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The disappearance time of clinical symptoms such as chest wheezing,shortness of breath,wheezing,chest tightness and cough in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TGF-β1,ERK,MMP-9 and VEGF in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The ACT scores of the two groups were higher than those before the treatment,that in the study group was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1) and FVC in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.0

关 键 词：哮喘 急性发作 苏黄止咳胶囊 茶碱缓释片 呼吸道重塑 肺功能 

分 类 号：R974[医药卫生—药品]