金水六君煎联合常规西药治疗稳定期慢性阻塞性肺疾病患者的效果  

Effects of Jinshui Liujun decoction combined with conventional Western medicine in treatment of patients with stable chronic obstructive pulmonary disease

作　　者：王伟晶 WANG Weijing(Nanjing Town Health Center of Quannan County,Ganzhou 341802 Jiangxi,China)

机构地区：[1]全南县南迳镇中心卫生院,江西赣州341802

出　　处：《中国民康医学》2024年第24期78-81,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察金水六君煎联合常规西药治疗稳定期慢性阻塞性肺疾病(COPD)患者的效果。方法:选取2021年2月至2024年2月该院收治的88例稳定期COPD患者进行前瞻性研究,按照随机数字表法将其分为观察组42例与对照组46例。对照组采用常规西药治疗,观察组在对照组基础上联合金水六君煎治疗,比较两组临床疗效,治疗前后炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-ɑ(TNF-α)、降钙素原(PCT)]水平、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)]水平、临床症状[日排痰量、改良版英国医学研究委员会呼吸问卷(mMRC)、COPD评估测试问卷(CAT)]、中医证候积分,以及不良反应发生率。结果:观察组治疗总有效率为95.24%(40/42),高于对照组的80.43%(37/46),差异有统计学意义(P<0.05);治疗后,两组CRP、PCT、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组FEV_(1)、FVC水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组日排痰量均少于治疗前,且观察组少于对照组,两组mMRC、CAT评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组胸闷气短、咳嗽痰稠、腰膝酸软等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:金水六君煎联合常规西药治疗稳定期COPD患者可提高治疗总有效率和肺功能指标水平,改善临床症状,降低炎性因子水平和中医证候积分的效果优于单纯常规西药治疗。Objective:To observe effects of Jinshui Liujun decoction combined with conventional Western medicine in treatment of patients with stable chronic obstructive pulmonary disease(COPD).Methods:A prospective study was conducted on 88 patients with stable COPD admitted to the hospital from February 2021 to February 2024.According to the random number table method,they were divided into observation group(42 cases)and control group(46 cases).The control group was treated with conventional Western medicine,while the observation group was treated with Jinshui Liujun decoction on the basis of that of the control group.The clinical efficacy,the levels of inflammatory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)]and lung function indexes[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)],the clinical symptoms[daily sputum volume,modified British medical research council respiratory questionnaire(mMRC),COPD assessment test(CAT)],the TCM syndrome score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.24%(40/42),which was higher than 80.43%(37/46)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CRP,PCT and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of FEV_(1) and FVC in the two groups were higher than those before the treatment,those in the observation group was higher than those in the control group,and the differences were statistically significant(P<0.05).The daily sputum volume of the two groups were less than those before the treatment,and that in the observation group was less than that in the control group;the mMRC and CAT scores of the two groups were lower than those before the treatment,and those in the obse

关 键 词：金水六君煎 稳定期 慢性阻塞性肺疾病 肺功能 炎性因子 中医证候积分 临床症状 

分 类 号：R563[医药卫生—呼吸系统]