PDW、MPV、FIB水平联合检测在早发型重度子痫前期患者不良妊娠结局诊断中的效能  

Efficiency of combined detection of PDW,MPV and FIB levels in diagnosis of adverse pregnancy outcomes in patients with early onset severe preeclampsia

作　　者：蒋丽 张金梅 JIANG Li;ZHANG Jinmei(Department of Clinical Laboratory of Xiangcheng Maternal and Child Health Hospital,Xiangcheng 466200 Henan,China)

机构地区：[1]项城市妇幼保健院检验科,河南项城466200

出　　处：《中国民康医学》2024年第24期109-111,118,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血小板体积分布宽度(PDW)、平均血小板体积(MPV)、纤维蛋白原(FIB)水平联合检测在早发型重度子痫前期患者不良妊娠结局诊断中的效能。方法:选取2020年11月至2023年1月该院收治的80例早发型重度子痫前期患者,设为研究组,另选取同期30名规律产检正常妊娠的孕妇作为对照组,比较两组及不同妊娠结局早发型重度子痫前期患者PDW、MPV、FIB水平。绘制受试者工作特征(ROC)曲线,分析PDW、MPV、FIB水平单项及联合检测在早发型重度子痫前期患者不良妊娠结局诊断中的效能。结果:研究组PDW、MPV、FIB水平均高于对照组,差异有统计学意义(P<0.05);不良妊娠结局患者PDW、MPV、FIB水平均高于良好妊娠结局患者,差异有统计学意义(P<0.05);经ROC曲线分析结果显示,PDW、MPV、FIB水平单项及联合检测诊断早发型重度子痫前期患者不良妊娠结局的曲线下面积分别为0.745、0.761、0.854、0.871,且联合检测的诊断效能高于三者单项检测。结论:PDW、MPV、FIB水平联合检测诊断早发型重度子痫前期患者不良妊娠结局的效能高于三者单项检测。Objective:To analyze efficiency of combined detection of platelet distribution width(PDW),mean platelet volume(MPV)and fibrinogen(FIB)in diagnosis of adverse pregnancy outcomes in patients with early onset severe preeclampsia.Methods:A total of 80 patients with early onset severe preeclampsia admitted to this hospital from November 2020 to January 2023 were selected as the study group.In addition,30 pregnant women with normal pregnancy during the same period were selected as the control group.The levels of PDW,MPV and FIB in patients with early onset severe preeclampsia with different pregnancy outcomes were compared between the two groups and the patients with early onset severe preeclampsia with different pregnancy outcomes.The receiver operating characteristic(ROC)curve was drawn to analyze the efficienciy of single and combined detection of PDW,MPV and FIB levels in the diagnosis of adverse pregnancy outcomes in the patients with early onset severe preeclampsia.Results:The levels of PDW,MPV and FIB in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of PDW,MPV and FIB in the patients with adverse pregnancy outcomes were higher than those in the patients with good pregnancy outcomes,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of PDW,MPV and FIB levels in the diagnosis of adverse pregnancy outcomes in the patients with early onset severe preeclampsia was 0.745,0.761,0.854 and 0.871,separately,and the diagnostic efficiency of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of PDW,MPV and FIB levels in the diagnosis of adverse pregnancy outcomes in the patients with early onset severe preeclampsia is higher than that of single detection of the three.

关 键 词：早发型重度子痫前期 血小板分布宽度 血小板平均体积 纤维蛋白原 妊娠结局 诊断 

分 类 号：R71[医药卫生—妇产科学]