A型肉毒毒素、果酸联合强脉冲光治疗痤疮瘢痕的效果  

Effect of Botulinum Toxin A, Glycolic Peeling Combined withIntense Pulse Laser on Acne Scars

作　　者：卓志媛 吴媛媛 杨茂省 ZHUO Zhiyuan;WU Yuanyuan;YANG Maosheng(Medical Cosmetology Department,Puyang Second People’s Hospital(Puyang Eye Hospital),Puyang 457000,China;External Eye Disease,Puyang Second People’s Hospital(Puyang Eye Hospital),Puyang 457000,China)

机构地区：[1]濮阳市第二人民医院(濮阳市眼科医院)医疗美容科,河南濮阳457000 [2]濮阳市第二人民医院(濮阳市眼科医院)外眼病,河南濮阳457000

出　　处：《河南医学研究》2024年第24期4463-4466,共4页Henan Medical Research

摘　　要：目的 探究A型肉毒毒素、果酸联合强脉冲光治疗痤疮瘢痕的效果及对面部改善情况、不良反应的影响。方法 选取2019年7月至2022年12月在濮阳市第二人民医院就诊的92例痤疮瘢痕患者为研究对象,经简单随机法分为观察组(46例)及对照组(46例)。对照组接受强脉冲激光进行治疗,观察组在其基础上联合A型肉毒毒素及果酸换肤。记录两组治疗1个月后临床效果[研究者总体评估(IGA评分)],比较治疗前、治疗2个月后两组痤疮瘢痕情况[痤疮瘢痕权重评分(ECCA)]、美观效果,记录两组治疗期间疼痛、红斑、水肿等不良反应发生情况。结果 治疗1个月后观察组治疗有效率高于对照组(P<0.05)。两组治疗2个月后ECCA评分、灰度差值均降低,且观察组低于对照组(P<0.05)。两组治疗期间不良反应发生率差异无统计学意义(P>0.05)。结论 A型肉毒毒素、果酸换肤联合强脉冲激光可改善痤疮瘢痕患者面部症状,且安全性较高,具有临床推广价值。Objective To explore the effect of botulinum toxin A,glycolic peeling combined with intense pulse laser in the treatment of acne scars and the influence on facial improvement and adverse reactions.Methods A total of 92 patients with acne scars treated in Puyang Second People’s Hospital were selected as the study subjects from July 2019 to December 2022,and were divided into observation group(46 cases)and control group(46 cases)by means of simple randomized method.The control group adopted intense pulse laser,and the observation group was combined with botulinum toxin A and glycolic peeling on this basis.The clinical effect[investigator global assessment(IGA)]in the two groups was recorded after 1 month of treatment.The acne scars[Echelle d’evaluation clinique des cicatrices d’acne(ECCA)]and aesthetic effect were compared before treatment and after 2 months of treatment.The occurrence of pain,erythema,edema and other adverse reactions during treatment were recorded in the two groups.Results The effective rate of treatment was higher in observation group than that in control group after 1 month of treatment(P<0.05).The ECCA score and gray difference were decreased in both groups after 2 months of treatment,and the above indicators in observation group were lower(P<0.05).The incidence rates of adverse reactions were not statistically different between groups during treatment(P>0.05).Conclusion The combination of botulinum toxin A,glycolic peeling and intense pulse laser can improve the facial symptoms in patients with acne scars,and it has high safety and clinical promotion value.

关 键 词：A型肉毒毒素 果酸换肤 强脉冲光 痤疮瘢痕 美观效果 

分 类 号：R751[医药卫生—皮肤病学与性病学]