C1q、Lp-PLA2、ADMA对原发性高血压患者心血管事件发生风险的评估价值  

Evaluation Value of C1q, Lp-PLA2 and ADMA on the Risk ofCardiovascular Events in Patients with Essential Hypertension

作　　者：张三 ZHANG San(Department of Clinical Laboratory,Xinzheng Huaxin People’s Hospital,Zhengzhou 451100,China)

机构地区：[1]新郑华信民生医院检验科,河南郑州451100

出　　处：《河南医学研究》2024年第24期4506-4510,共5页Henan Medical Research

摘　　要：目的 分析补体1q(C1q)、脂蛋白相关磷脂酶A2(Lp-PLA2)、非对称二甲基精氨酸(ADMA)对原发性高血压患者心血管事件发生风险的评估价值。方法 2021年1月至2023年2月新郑华信民生医院收治的156例原发性高血压并发心血管事件患者纳入研究组,另择同期168例原发性高血压未并发心血管事件患者纳入对照组。分析两组临床特征、常规生化指标、血清C1q、Lp-PLA2、ADMA水平,通过多因素分析法分析原发性高血压患者发生心血管事件的危险因素,绘制受试者工作特征(ROC)曲线分析相关指标对原发性高血压患者发生心血管事件的评估价值。结果 多因素logistic分析结果显示,体重指数(BMI)升高、合并糖尿病、高血压分级3级、血清Lp-PLA2及ADMA水平升高为原发性高血压患者发生心血管事件的危险因素(OR=1.988、2.063、2.020、2.083、2.326,P<0.05);血清C1q水平升高为原发性高血压患者发生心血管事件的保护因素(OR=0.534,P<0.05)。将原发性高血压患者发生心血管事件纳入阳性,未发生心血管事件纳入阴性,绘制ROC曲线分析C1q、Lp-PLA2、ADMA单独及联合检测对原发性高血压患者发生心血管事件的评估价值,曲线下面积(AUC)为0.785、0.852、0.781、0.916,敏感度为75.00%、79.49%、69.23%、89.74%,特异度为67.86%、79.76%、78.57%、81.55%,联合检测均最高。结论 原发性高血压患者心血管事件发生的危险因素包括BMI升高、合并糖尿病、高血压分级3级、血清C1q水平降低、Lp-PLA2、ADMA水平升高,C1q、Lp-PLA2及ADMA联合检测对原发性高血压患者心血管事件发生风险的评估价值较高,可为临床干预方案的选择提供依据。Objective To analyze the value of complement 1q(C1q),lipoprotein-associated phospholipase A2(Lp-PLA2)and asymmetric dimethylarginine(ADMA)in evaluating the risk of cardiovascular events in patients with essential hypertension.Methods A total of 156 patients with essential hypertension with cardiovascular events admitted to Xinzheng Huaxin People’s Hospital from January 2021 to February 2023 were included in the study group,and another 168 patients with essential hypertension without cardiovascular events were included in the control group.The clinical features,routine biochemical indicators,serum levels of C1q,Lp-PLA2 and ADMA of the two groups were analyzed.The risk factors of cardiovascular events in patients with essential hypertension were analyzed by multivariate logistic analysis,and the value of relevant indicators in evaluating cardiovascular events in patients with essential hypertension was analyzed by receiver operating characteristics(ROC)curve.Results The results of multivariate logistic analysis showed that the risk factors for cardiovascular events in patients with essential hypertension were body mass index(BMI)increased,combined with diabetes,hypertension grade 3,and elevated serum levels of Lp-PLA2,ADMA(OR=1.988,2.063,2.020,2.083,2.326,P<0.05).Increased serum level of C1q was a protective factor for cardiovascular events in patients with essential hypertension(OR=0.534,P<0.05).Patients with essential hypertension with cardiovascular events were included as positive and those without cardiovascular events as negative.ROC curve was drawn to analyze the evaluation value of C1q,Lp-PLA2 and ADMA alone and in combination on cardiovascular events in patients with essential hypertension,with area under the curve(AUC)values of 0.785,0.852,0.781 and 0.916,respectively.The sensitivities were 75.00%,79.49%,69.23%,89.74%,respectively,and the specificities were 67.86%,79.76%,78.57%,81.55%,respectively,all of which combined detection were the highest.Conclusion The risk factors for cardiovascular events in p

关 键 词：原发性高血压 心血管事件 危险因素 补体1q 脂蛋白相关磷脂酶A2 非对称二甲基精氨酸 评估价值 

分 类 号：R544.1[医药卫生—心血管疾病]