消囊调经汤联合炔雌醇环丙孕酮治疗多囊卵巢综合征的效果  

Effects of Xiaonang Tiaojing Decoction Combined with EthinylestradiolCyproterone in Patients with Polycystic Ovary Syndrome

作　　者：孙培培[1] 袁俊俊 周艳艳[3] SUN Peipei;YUAN Junjun;ZHOU Yanyan(Department of Obstetrics,Zhengzhou Second People’s Hospital,Zhengzhou 450000,China;Department of Obstetrics and Gynaecology,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Obstetrics and Gynecology,Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]郑州市第二人民医院产科,河南郑州450000 [2]河南中医药大学第三附属医院妇产科,河南郑州450000 [3]河南省中医院妇产科,河南郑州450002

出　　处：《河南医学研究》2024年第24期4547-4550,共4页Henan Medical Research

基　　金：河南省科技攻关计划项目(212102311138);河南省中医药科学研究专项课题(2023ZY2100)。

摘　　要：目的 探究消囊调经汤联合炔雌醇环丙孕酮治疗多囊卵巢综合征(PCOS)的效果。方法 将2019年10月至2021年5月郑州市第二人民医院收治的118例PCOS患者随机分为两组。西药组(59例)口服炔雌醇环丙孕酮片治疗,联合组(59例)在西药组基础上接受消囊调经汤治疗。两组均接受3个月经周期的治疗,治疗后比较中医症候积分、临床疗效、卵巢形态以及血流动力学。结果 联合组中医证候积分低于西药组(P<0.05);联合组临床总有效率(91.53%)高于西药组(76.27%)(P<0.05);联合组卵巢体积、包膜厚度、卵泡数量小于西药组,卵泡最大直径大于西药组(P<0.05);联合组卵巢动脉收缩期最大流速和舒张末期速度高于西药组,血流搏动指数以及阻力指数低于西药组(P<0.05);联合组不良反应率低于西药组(P<0.05)。结论 消囊调经汤联合炔雌醇环丙孕酮治疗PCOS效果显著,对PCOS患者的卵巢形态及血流动力学指标起到改善作用。Objective To explore the effect of Xiaonang Tiaojing Decoction combined with ethinylestradiol cyproterone in patients with polycystic ovary syndrome(PCOS).Methods A total of 118 patients with PCOS admitted to Zhengzhou Second People’s Hospital from October 2019 to May 2021 were randomly divided into two groups.The Western medicine group(59 patients)were treated with oral ethinylestradiol cycloproterenol tablets,while the combined group(59 patients)were treated with Xiaonang Tiaojing Decoction on the basis of the Western medicine group.Both groups were treated for three consecutive menstrual cycles and traditional Chinese medicine symptom scores,clinical efficacy,ovarian morphology,and hemodynamics after treatment were compared.Results The traditional Chinese medicine symptom scores in the combined group was lower than that in the Western medicine group(P<0.05).The total clinical effective rate of the combined group(91.53%)was higher than that of the Western medicine group(76.27%)(P<0.05).The ovarian volume,capsule thickness,and number of follicles in the combined group were smaller than those in the Western medicine group,while the maximum diameter of follicles was larger than those in the Western medicine group(P<0.05).The maximum systolic velocity and end diastolic velocity of the ovarian artery in the combined group were higher than those in the Western medicine group,while the pulsatile index and resistance index of the blood flow were lower than those in the Western medicine group(P<0.05).The adverse reaction rate of the combined group was lower than that of the Western medicine group(P<0.05).Conclusion The combination of Xiaonang Tiaojing Decoction and ethinylestradiol cycloproterenol has a significant therapeutic effect on PCOS,and has a significant improvement effect on ovarian morphology and hemodynamic indicators in PCOS patients.

关 键 词：多囊卵巢综合征 消囊调经汤 炔雌醇环丙孕酮 卵巢形态 血流动力学 

分 类 号：R711.75[医药卫生—妇产科学]