基于子午流注理论探讨昼夜节律对青光眼眼压节律紊乱的影响  

Effects of circadian rhythm on intraocular pressure rhythm disruption in glaucoma based on the theory of midnight-noon ebb-flow

作　　者：李文娟[1,2] 谭涵宇 时健[1,2] 彭榆津 彭清华 彭俊 LI Wenjuan;TAN Hanyu;SHI Jian;PENG Yujin;PENG Qinghua;PENG Jun(Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of Chinese Medicine for the Prevention and Treatment of Eye,Ear,Nose and Throat Diseases,Changsha 410208,China;The first Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]中医药防治眼耳鼻喉疾病湖南省重点实验室,湖南长沙410208 [3]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《湖南中医药大学学报》2024年第12期2299-2303,共5页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金面上项目(82274588);湖南省自然科学基金项目(2024JJ6348);湖南省中医药科研课题(B2023093,D2022045);湖南中医药大学揭榜挂帅科研项目(2022XJJB003);湖南中医药大学本科生科研创新基金项目(2023BKS165);湖南中医药大学本科生科研创新基金项目(2023BKS166)。

摘　　要：子午流注理论是中医时间医学的一部分,它将一天24小时划分为十二时辰,与人体十二脏腑的气血运行相结合,体现了昼夜节律性。青光眼患者眼压的生理性波动与病理性波动均与脏腑、经络功能相关。眼压昼夜波动的形成机制涉及多因素调控,包括生物钟、褪黑素水平以及内在光敏视网膜神经节细胞的功能。本文通过分析子午流注理论与昼夜节律的相关性,探讨昼夜节律对青光眼眼压节律紊乱的影响,并提出中医药治疗青光眼的新策略,为青光眼的临床治疗提供新的视角和方法。The theory of midnight-noon ebb-flow is a part of chronomedicine of Chinese medicine.It divides a 24-hour day into twelve two-hour periods,each corresponding to the qi and blood circulation of the twelve zang-fu organs in human body,reflecting the circadian rhythm.Both physiological and pathological fluctuations of intraocular pressure in glaucoma patients are related to the functions of zang-fu organs and meridians.The mechanism underlying the diurnal fluctuation in intraocular pressure involves multifactorial regulation,including the biological clock,melatonin levels,and the function of intrinsic photosensitive retinal ganglion cells.By analyzing the correlation between the theory of midnight-noon ebb-flow and the circadian rhythm,this article explores the effects of circadian rhythm on intraocular pressure rhythm disruption in glaucoma.It further proposes new strategies for treating glaucoma with Chinese medicine,providing novel perspectives and approaches for the clinical treatment of glaucoma.

关 键 词：青光眼 子午流注 昼夜节律 择时治疗 眼压 节律紊乱 

分 类 号：R276.7[医药卫生—中医五官科学]