Ultrasonic assisted natural deep eutectic solvents as a green and efficient approach for extraction of hydroxytyrosol from olive leaves  

作　　者：Mingming Hu Bao Han Lin Xie Beibei Lu De Bai Nuo Shi Ya Liao Yan Wang Ling Liu Shaojun Wu Runrui Lan Xiaomei Lei Ci Shi Danhua Huang Yuanbin Li Lin Lin Jiaheng Zhang 

机构地区：[1]Sauvage Laboratory for Smart Materials,Harbin Institute of Technology(Shenzhen),Shenzhen 518055,P.R.China [2]Research Centre of Printed Flexible Electronics,School of Materials Science and Engineering,Harbin Institute of Technology(Shenzhen),Shenzhen 518055,P.R.China [3]Shenzhen Shinehigh Innovation Technology Co.,Ltd,Shenzhen 518055,P.R.China [4]Shanghai Corday Biotech.Co.,Ltd,Shanghai 200000,P.R.China

出　　处：《Industrial Chemistry & Materials》2024年第2期309-320,共12页工业化学与材料（英文）

基　　金：financially supported by the National Natural Science Foundation of China(21905069,U21A20307),the Shenzhen Science and Technology Innovation Committee(Grant No.ZDSYS20190902093220279,KQTD20170809110344233,GXWD20201230155427003-20200821181245001,GXWD20201230155427003-20200821181809001,ZX20200151);the Department of Science and Technology of Guangdong Province(Grant No.2020A1515110879).

摘　　要：In this study,an ultrasonic assisted natural deep eutectic solvent(DES)was used to extract hydroxytyrosol(HT)from olive leaves.The optimal extraction conditions of the MaPa-4 concentration,extraction time and solid-liquid ratio were obtained by single factor experiments.The formation mechanism of MaPa and its interaction with HT were analyzed by FTIR,^(1)H-NMR and density functional theory(DFT)calculation.Then,MaPa-4 and water extracts obtained under the optimal extraction conditions were selected for a series of efficacy tests.MaPa-4 extract demonstrated low cytotoxicity,good biocompatibility,and excellent antiinflammatory and bacteriostatic properties.Overall,MaPa-4,as an environmentally friendly and efficient solvent,was combined with ultrasound treatment to develop an efficient,green and feasible method to extract HT from olive leaves.

关 键 词：Hydroxytyrosol Deep eutectic solvent Single-factor experiment BACTERIOSTATIC ANTIINFLAMMATORY ANTIOXIDANT 

分 类 号：TG1[金属学及工艺—金属学]