真实世界单中心超早产儿救治分析  

Analysis of treatment outcomes of extremely preterm infants in a real-world single center

作　　者：夏磊[1] 赵家文 王慧娟 乔青 武田博 武慧杰 XIA Lei;ZHAO Jia-Wen;WANG Hui-Juan;QIAO Qing;WU Tian-Bo;WU Hui-Jie(Department of Neonatology,Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院新生儿科,河南郑州450052

出　　处：《中国当代儿科杂志》2024年第12期1335-1340,共6页Chinese Journal of Contemporary Pediatrics

基　　金：河南省医学科技攻关联合共建项目(LHGJ20220540)。

摘　　要：目的探讨超早产儿的救治情况。方法回顾性分析郑州大学第三附属医院新生儿重症监护室2016年1月—2022年12月收治的超早产儿临床资料。将入组的早产儿分为非院内死亡组和存活组,采用SPSS 29.0进行数据分析。结果共纳入超早产儿422例,其中非院内死亡组155例,存活组267例。非院内死亡组胎龄、出生体重、剖宫产率、母亲胎膜早破>18 h比例均低于存活组,而Apgar 1 min评分≤3分、气管插管、新生儿呼吸窘迫综合征、早发型败血症、脑室周围-脑室内出血(Ⅲ~Ⅳ级)、肺出血等发生比例高于存活组,差异均有统计学意义(P<0.05)。结论胎龄小、出生体重低、出生窒息病史及严重颅内出血、肺出血是导致超早产儿发生非院内死亡的主要原因,因此需做好围产期保健,减少窒息、严重疾病的发生。Objective To study the treatment outcomes of extremely preterm infants.Methods A retrospective analysis was performed for the clinical data of extremely preterm infants who were admitted to the neonatal intensive care unit of the Third Affiliated Hospital of Zhengzhou University from January 2016 to December 2022.The infants were divided into a non-in-hospital death group and a survival group.SPSS 29.0 was used for data analysis.Results A total of 422 extremely preterm infants were included,of which 155 were in the non-in-hospital death group and 267 in the survival group.The gestational age,birth weight,cesarean section rate,and proportion of mothers with premature rupture of membranes>18 hours in the non-in-hospital death group were all lower than those in the survival group(P<0.05).In contrast,the proportions of Apgar score≤3 at 1 minute,intubation,neonatal respiratory distress syndrome,early-onset sepsis,periventricular-intraventricular hemorrhage(grades III-IV),and pneumorrhagia were higher in the non-in-hospital death group compared to the survival group(P<0.05).Conclusions Low gestational age,low birth weight,the history of birth asphyxia,severe intracranial hemorrhage,and pneumorrhagia may be the main causes of non-in-hospital death in extremely preterm infants,and therefore,perinatal health care should be enhanced to reduce the onset of asphyxia and severe diseases.

关 键 词：胎龄 治疗 超早产儿 

分 类 号：R722.6[医药卫生—儿科]