伽玛刀立体定向放射外科治疗不良事件分析  

Analysis of adverse events in stereotactic radiosurgery with Gamma Knife

作　　者：张明群 钱大棣 刘小瑜 左丽 王克万[2] Zhang Mingqun;Qian Dadi;Liu Xiaoyu;Zuo Li;Wang Kewan(Department of Medical Device Monitoring,Shen Zhen Institute of Pharmacovigilance and Risk Management,Shenzhen 518000,China;The Gamma Knife Center of Neurosurgical department,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]深圳市药物警戒和风险管理研究院器械监测部,深圳518000 [2]南方医科大学南方医院神经外科伽玛刀中心,广州510515

出　　处：《中国医学装备》2024年第12期178-184,共7页China Medical Equipment

基　　金：国家“十三五”医疗器械不良事件重点监测项目(食药监办械监2016173号)。

摘　　要：伽玛刀立体定向放射外科治疗是高度精准的放射治疗技术,包括头部伽玛刀治疗系统和体部伽玛刀治疗系统,通过多线束伽玛射线聚焦照射特定的靶区,使病灶部位受到高剂量辐射产生放射性损伤及坏死,靶区以外剂量锐减,从而保护靶区外正常组织。伽玛刀治疗具有微创、疗效确实等优点,由于其精准和陡降的剂量分布,不良反应相对较少,可以部分替代手术或做为手术后的补充治疗。伽玛刀最初用于颅脑疾病的治疗,我国首先将其应用于体部肿瘤的治疗。随着伽玛刀放射外科技术广泛应用,伽玛刀放射治疗的不良事件也在增加,主要包括治疗设备故障和操作不当导致的不良事件,以及组织放射损伤导致的不良事件及并发症。综述并分析伽玛刀使用过程中相关不良事件,探讨伽玛刀不良事件的类型、成因、预防措施及应对策略,以期为伽玛刀的安全使用提供理论支持和实践指导。Gamma Knife stereotactic radiosurgery is a highly precise radiotherapy technology,including the head Gamma Knife treatment system and the body Gamma Knife treatment system.Through multi-beam gamma rays focused on a specific target area,the lesion is exposed to high-dose radiation to cause radiation damage and necrosis,and the dose outside the target area is sharply reduced,thereby protecting the normal tissue outside the target area.Gamma Knife treatment has the advantages of being minimally invasive and effective treatment.Due to its precise and steep dose distribution,side effects are relatively few,and it can partially replace surgery or serve as a supplementary treatment after surgery.It was originally used for the treatment of craniocerebral diseases.In my country,Gamma Knife treatment was first applied to the treatment of body tumors.In recent years,with the widespread application of Gamma Knife radiosurgery technology,the incidence of adverse events associated with Gamma Knife radiotherapy has also increased.Gamma Knife adverse events mainly include those caused by treatment equipment failure and improper operation,as well as adverse events and complications resulting from tissue radiation damage.This article aims to comprehensively review and analyze the adverse events related to the use of Gamma Knife,and to explore the types,causes,preventive measures and coping strategies of these adverse events,in order to provide theoretical support and practical guidance for the safe use of Gamma Knife.

关 键 词：伽玛刀 不良事件 立体定向放射外科 预防措施 

分 类 号：R812[医药卫生—放射医学]