青中年甲状腺结节患者甲状腺功能与甲状腺结节数量及良恶性的相关性研究  

Correlation between Thyroid Function and the Number,Benign and Malignant of Thyroid Nodules in Young and Middle-aged Patients with Thyroid Nodules

作　　者：李巍巍 杨青 Li weiwei;Yang Qing(Department of Endocrinology,Suzhou Yongding Hospital,Suzhou 215200,Jiangsu Province,China)

机构地区：[1]苏州永鼎医院内分泌科,江苏苏州215200

出　　处：《中外医药研究》2024年第31期141-143,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨青中年甲状腺结节患者甲状腺功能与甲状腺结节数量及良恶性的相关性。方法:选取2022年1月—2023年10月在苏州永鼎医院内分泌科治疗的甲状腺结节患者120例作为研究对象,均接受甲状腺超声及甲状腺功能检测。比较不同甲状腺结节数量(单发与多发)、性质(良性与恶性)患者血清甲状腺素(TSH)、游离甲状腺素(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))水平,分析甲状腺结节良恶性质、结节数量与血清TSH、FT_(4)、FT_(3)水平的相关性。结果:单发结节组与多发结节组血清TSH、FT_(4)、FT_(3)水平比较,差异无统计学意义(P>0.05)。恶性结节组血清TSH水平高于良性结节组,FT_(4)、FT_(3)水平低于良性结节组,差异有统计学意义(P<0.05)。血清TSH、FT_(4)、FT_(3)表达水平与甲状腺结节数量无相关性(P>0.05);血清TSH水平与甲状腺结节良恶性质呈正相关,血清FT_(4)、FT_(3)水平与甲状腺结节良恶性质呈负相关(P<0.05)。结论:TSH、FT_(4)、FT_(3)水平与甲状腺结节数量无关,血清TSH水平与甲状腺结节良恶性质呈正相关,血清FT_(4)、FT_(3)水平与甲状腺结节良恶性质呈负相关。Objective:To investigate the correlation between thyroid function and the number of thyroid nodules,benign and malignant in young and middle-aged patients with thyroid nodules.Methods:A total of one hundred and twenty patients with thyroid nodules treated in the Department of Endocrinology of Suzhou Yongding Hospital from January 2022 to October 2023 were selected as the study objects,and all of them received thyroid ultrasound and thyroid function tests.The levels of serum thyroxine(TSH),free thyroxine(FT_(4))and free triiodothyronine(FT_(3))in patients with different number(single and multiple)and nature(benign and malignant)of thyroid nodules were compared.The correlation between the benign and malignant properties of thyroid nodules,the number of nodules and serum TSH,FT_(4)and FT_(3)levels was analyzed.Results:There was no significant difference in serum TSH,FT_(4)and FT_(3)levels between the single nodule group and the multiple nodule group(P>0.05).The serum TSH level in the malignant nodule group was higher than that in the benign nodule group,and the serum FT_(4)and FT_(3)levels were lower than those in the benign nodule group,the difference was statistically significant(P<0.05).The expression levels of serum TSH,FT_(4)and FT_(3)were not correlated with the number of thyroid nodules(P>0.05);serum TSH levels were positively correlated with the benign and malignant properties of thyroid nodules,and serum FT_(4)and FT_(3)levels were negatively correlated with the benign and malignant properties of thyroid nodules(P<0.05).Conclusion:TSH,FT_(4)and FT_(3)levels are not correlated with the number of thyroid nodules,serum TSH levels are positively correlated with the benign and malignant properties of thyroid nodules,while serum FT_(4)and FT_(3)levels are negatively correlated with the benign and malignant properties of thyroid nodules.

关 键 词：青中年 甲状腺功能 甲状腺结节 相关性 

分 类 号：R581[医药卫生—内分泌]