炎症四项和T淋巴细胞亚群联合检测与系统性红斑狼疮的相关性分析  

Analysis of Correlation between the Four Factors of Inflammation and T Lymphocyte Subsets and Systemic Lupus Erythematosus

作　　者：吴声楹 黄朝任 邹光美 杨小兰[1] 梁梅[1] Wu Shengying;Huang Chaoren;Zou Guangmei;Yang Xiaolan;Liang Mei(Yulin First People's Hospital,Yulin 537000,Guangxi Zhuang Autonomous Region,China;Yulin Hospital of Traditional Chinese Medicine,Yulin 537000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]玉林市第一人民医院,广西壮族自治区玉林537000 [2]玉林市中医医院,广西壮族自治区玉林537000

出　　处：《中外医药研究》2024年第32期151-153,156,共4页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：玉林市科学研究与技术开发计划课题(编号:玉市科20204402);广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20211083)。

摘　　要：目的:分析炎症四项和T淋巴细胞亚群与系统性红斑狼疮(SLE)的相关性。方法:选取2020年10月—2023年5月玉林市第一人民医院收治的SLE患者(SLE组,n=92)及同期健康体检者(对照组,n=46)作为研究对象。分别检测两组炎症四项、T淋巴细胞亚群水平,进行比较与分析。结果:SLE组血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)水平均高于对照组(P<0.001);SLE组CD3%、CD8%高于对照组,CD4%/CD8%低于对照组(P<0.001);SLE组CD3#、CD4#、CD8#均低于对照组(P<0.001);Logistic回归分析显示,SAA、IL-6、CD8%、CD8#是SLE患者的危险因素,CD3#是SLE患者的保护因素(P<0.05)。Spearman相关分析结果显示,SAA与IL-6、PCT、CRP呈正相关(P<0.05);CD4%与CD3%、CD4%/CD8%、CD4#呈正相关(P<0.05),CD4%与CD8%呈负相关(P<0.05)。结论:炎症四项及T淋巴细胞亚群水平与SLE发生、发展密切相关,联合检测筛查危险因素对SLE的规范诊疗有重要的指导价值。Objective:To analyze the correlation between inflammation and T lymphocyte subsets and systemic lupus erythematosus(SLE).Methods:SLE patients admitted to Yulin First People's Hospital from October 2020 to May 2023(SLE group,n=92)and healthy people who underwent physical examination during the same period(control group,n=46)were selected as the study objects.The levels of four inflammatory items and T lymphocyte subsets in the two groups were detected respectively for comparison and analysis.Results:Serum levels of amyloid A(SAA),interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)in SLE group were higher than those in control group(P<0.001);CD3%and CD8%in SLE group were higher than those in control group,and CD4%/CD8%were lower than those in control group(P<0.001);CD3#,CD4#and CD8#in SLE group were lower than those in control group(P<0.001);Logistic regression analysis showed that SAA,IL-6,CD8%and CD8#were risk factors for SLE patients,and CD3#were protective factors for SLE patients(P<0.05).Spearman correlation analysis showed that SAA was positively correlated with IL-6,PCT and CRP(P<0.05);CD4%was positively correlated with CD3%,CD4%/CD8%and CD4#(P<0.05),and CD4%was negatively correlated with CD8%(P<0.05).Conclusion:The four inflammatory factors and the level of T lymphocyte subsets are closely related to the occurrence and development of SLE.The combined detection and screening of risk factors have important guiding value for the standardized diagnosis and treatment of SLE.

关 键 词：系统性红斑狼疮 血清淀粉样蛋白A 白细胞介素-6 降钙素原 C反应蛋白 T淋巴细胞亚群 

分 类 号：R593.241[医药卫生—内科学]