N6-甲基腺苷修饰在糖尿病肾脏疾病中的机制研究进展  

Research advances on the mechanism of N6-methyladenosine modification in diabetic kidney disease

作　　者：陈建宇 谢婷妃 许云鹏 张燕子 隋晓露 张艾莎 陈继红 Chen Jian-yu;Xie Ting-fei;Xu Yun-peng;Zhang Yan-zi;Sui Xiao-lu;Zhang Ai-sha;Chen Ji-hong(Second People’s Hospital of Shenzhen,Shenzhen 518035,China;First Affiliated Hospital,Shenzhen University,Shenzhen 518061,China;People's Hospital of Bao’an Shenzhen,Second School of Clinical Medicine,Southern Medical University,Shenzhen 518100,China;Second Affiliated Hospital,Shenzhen University,Shenzhen 518054,China)

机构地区：[1]深圳市第二人民医院,深圳518035 [2]深圳大学附属第一医院,深圳518061 [3]南方医科大学第二临床医学院附属深圳市宝安区人民医院,深圳518100 [4]深圳大学附属第二医院,深圳518054

出　　处：《临床肾脏病杂志》2024年第12期1040-1044,共5页Journal Of Clinical Nephrology

基　　金：国家自然科学基金项目(82170712);深圳市医学重点学科建设经费资助(SZXK009);深圳市医疗卫生三名工程(SZSM202211013);深圳市高水平医院建设专项经费资助(20203357012)。

摘　　要：N6-甲基腺苷(N6-methyladenosine,m6A)修饰是指在核糖核酸(ribonucleic acid,RNA)的腺苷N6位点添加一个甲基,是真核RNA中最普遍、最丰富和最保守的内部共转录修饰,调控RNA的剪切、稳定性、翻译等,从而影响多种生物学过程,如肿瘤分化、代谢、免疫、干性维持等,与癌症、动脉硬化、糖尿病、心血管疾病等有关。近年来许多研究报道m6A修饰与糖尿病肾脏疾病(diabetic kidney disease,DKD)密切相关。本文通过对该领域的相关研究进行归纳总结,探索DKD中m6A相关基因及其调控机制,并总结了针对m6A修饰的药物干预措施以延缓DKD的研究进展,为早期诊断和治疗DKD探索新的靶点提供重要参考。As the most common,abundant and conserved internal cotranscriptional modification in eukaryotic ribonucleic acid(RNA),N6-methyladenosine(m6A)modification regulates RNA shear,sta-bility and translation,thus affecting a great variety of biological processes,such as tumor differentiation,metabolism,immunity and dry maintenance,etc.It is associated with tumorigenesis,arteriosclerosis,dia-betes mellitus and cardiovascular disease.In recent years,many studies have reported that m6A modifica-tion is correlated closely with diabetic kidney disease(DKD).This review explored m6A related genes and their regulatory mechanisms in diabetic kidney disease(DKD)and summarized drug interventions target-ing m6A modification for delaying the research progress of DKD,providing important references for ex-ploring new targets for early diagnosis and treatment of DKD.

关 键 词：N6-甲基腺苷修饰 糖尿病肾脏疾病 表观遗传学 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]