己酸铁的合成、结构表征及其抑菌活性研究  

Study on Synthesis,Structural Characterization and Antimicrobial Activity of Iron Caproate

作　　者：许继隆 乔汉桢 刘晴雨 王情原 姜悦 杨钰霖 李佳一 王金荣[1] XU Jilong;QIAO Hanzhen;LIU Qingyu;WANG Qingyuan;JIANG Yue;YANG Yulin;LI Jiayi;WANG Jinrong(College of Biological Engineering,Henan University of Technology,Henan Zhengzhou 450001,China)

机构地区：[1]河南工业大学生物工程学院,河南郑州450001

出　　处：《饲料工业》2024年第24期102-109,共8页Feed Industry

基　　金：河南工业大学创新基金支持计划专项[2020ZKCJ25];河南工业大学青年骨干教师培育计划项目[21421204]。

摘　　要：试验以己酸和硫酸铁为原料,采用皂化-复分解法合成己酸铁,并利用傅里叶红外光谱、X-射线衍射、粒度分析对合成的己酸铁进行结构表征,探究其对大肠杆菌和金黄色葡萄球菌抑菌特性。结果表明:己酸铁具有典型金属皂的特征,粒度均一,平均粒径为18.757μm,己酸通过双齿桥联配位铁原子。己酸铁对金黄色葡萄球菌和大肠杆菌的最小抑菌浓度与最小杀菌浓度分别为2000、4000μg/mL。己酸铁通过改变细胞膜通透性影响溶液电导率,并造成核酸和蛋白质泄漏,破坏细胞膜完整性抑制大肠杆菌和金黄色葡萄球菌。综上所述,己酸铁可通过破坏细菌细胞膜结构对金黄色葡萄球菌和大肠杆菌发挥抑菌作用,具有成为抗生素替代品的潜质。This experiment aimed to synthesize iron caprylate using caprylic acid and iron sulfate as raw materials and to explore its antibacterial activity.The iron caprylate was synthesized using the saponification-complex decomposition method,and its structure was characterized using Fourier transform infrared spectroscopy,X-ray diffraction,and particle size analysis.The antibacterial properties of the synthesized iron caprylate against Escherichia coli and Staphylococcus aureus were investigated.The results indicated that the iron caprylate exhibited typical characteristics of metal soaps,with uniform particle size distribution and an average particle size of 18.757μm.The caprylate coordinated with iron atoms through bidentate bridging.The minimum inhibitory concentration and minimum bactericidal concentration of iron caprylate against Staphylococcus aureus and Escherichia coli were found to be 2000 and 4000μg/mL,respectively.Iron caprylate was observed to affect the solution conductivity by altering the cell membrane permeability,leading to leakage of nucleic acids and proteins,and disrupting the integrity of the cell membrane,thereby inhibiting the growth of Escherichia coli and Staphylococcus aureus.In conclusion,iron caprylate can exert antibacterial effects against Staphylococcus aureus and Escherichia coli by disrupting the bacterial cell membrane structure,and it has the potential to serve as an alternative to antibiotics.

关 键 词：己酸铁 皂化-复分解法 结构表征 抑菌 中链脂肪酸 

分 类 号：S816.7[农业科学—饲料科学]