中老年2型糖尿病患者合并认知功能障碍的相关因素  

Related factors of cognitive impairment in middle-aged and old-aged patients with type 2 diabetes mellitus

作　　者：王家钰 柴扬帆 李启润 马俊[2] 高莹[4] 刘薇[4] 黄有媛[4] 张岩[5] 贾佳[5] 王淑玉 王闻博[7] 东黎光[7] 王安平[8] 司英奎 孔桂兰 张健[4] 张俊清[4] WANG Jiayu;CHAI Yangfan;LI Qirun;MA Jun;GAO Ying;LIU Wei;HUANG Youyuan;ZHANG Yan;JIA Jia;WANG Shuyu;WANG Wenbo;DONG Liguang;WANG Anping;SI Yingkui;KONG Guilan;ZHANG Jian;ZHANG Junqing(Institute of Medical Technology,Peking University Health Science Center,Beijing 100191,China;National Institute of Health Data Science,Peking University,Beijing 100191,China;Peking University Chongqing Research Institute of Big Data,Chongqing 400015,China;Department of Endocrinology,Peking University First Hospital,Beijing 100034,China;Department of Cardiol-ogy,Peking University First Hospital,Beijing 100034,China;Beijing Hypertension League Institute,Beijing 100043,China;Department of Endocrinology,Peking University Shougang Hospital,Beijing 100144,China;Department of Endocrinology,Chi-nese PLA General Hospital,Beijing 100039,China;Advanced Institute of Information Technology,Peking University,Hangzhou 314201,China)

机构地区：[1]北京大学医学部医学技术研究院,北京100191 [2]北京大学健康医疗大数据国家研究院,北京100191 [3]北京大学重庆大数据研究院,重庆400015 [4]北京大学第一医院内分泌科,北京100034 [5]北京大学第一医院心血管内科,北京100034 [6]北京市高血压病联盟研究所,北京100043 [7]北京大学首钢医院内分泌科,北京100144 [8]中国人民解放军总医院内分泌科,北京100039 [9]浙江省北大信息技术高等研究院,杭州314201

出　　处：《中国心理卫生杂志》2025年第1期13-19,共7页Chinese Mental Health Journal

基　　金：教育部人文社会科学项目(22YJA630036);浙江省自然科学基金重点项目(LZ22F020014);国家自然科学基金面上项目(82372095);北京市自然科学基金面上项目(7212201)。

摘　　要：目的:探讨中年和老年两个年龄段的2型糖尿病(T2DM)患者合并认知功能障碍的相关因素。方法:2018年9月至12月在北京市一大型社区居民中筛选出970名T2DM患者(中年585例,老年385例)。用简易精神状态量表(MMSE)评估认知功能。使用多因素logistic回归进行相关因素分析。结果:认知功能障碍检出率中年组12.0%,老年组13.5%。在中年T2DM人群中,工作(OR=0.22,95%CI:0.03~0.77)和受教育程度为大专/本科及以上(OR=0.18,95%CI:0.04~0.55)是保护因素,合并心梗(OR=4.13,95%CI:1.26~13.63)是危险因素。在老年T2DM人群中,每周饮茶1~2次(OR=0.11,95%CI:0.01~0.58)和受教育程度为大专/本科及以上(OR=0.19,95%CI:0.05~0.54)是保护因素,合并脑卒中(OR=3.64,95%CI:1.55~8.39)和很好的睡眠自我评价(OR=2.75,95%CI:1.13~7.35)是危险因素。结论:中年T2DM患者合并认知功能障碍与工作、受教育程度和心梗有关,老年T2DM患者合并认知功能障碍与生活方式、受教育程度和脑卒中有关。Objective:To investigate the related factors of cognitive impairment in middle-aged and old-aged patients with type 2 diabetes mellitus(T2DM).Methods:A total of 970 patients with T2DM(585 middle-aged group and 385 old-aged group)were selected from residents of a large community in Beijing from September to December 2018.The Mini-Mental State Examination(MMSE)was used to assess the cognitive function.Multivariate logistic regression was used to analyze the related factors.Results:The detection rates of cognitive impairment were 12.0% and 13.5%in middle-aged and old-aged patients with T2DM,respectively.Among middle-aged patients with T2DM,work(OR=0.22,95% CI:0.03-0.77)and education at the junior college or undergraduate level and above(OR=0.18,95%CI:0.04-0.55)were protective factors for cognitive impairment.Myocardial infarction(OR=4.13,95%CI:1.26-13.63)was a risk factor for cognitive impairment.Among old-aged patients with T2DM,drinking tea 1-2 times a week(OR=0.11,95% CI:0.01-0.58)and education at the junior college or undergraduate level and above(OR=0.19,95%CI:0.05-0.54)were protective factors for cognitive impairment.Stroke(OR=3.64,95%CI:1.55-8.39)and good sleep self-assessment(OR=2.75,95% CI:1.13-7.35)were risk factors for cognitive impairment.Conclusion:Cognitive impairment in middle-aged patients with T2DM is related to work,education level and myocardial infarction,and cognitive impairment in oldaged patients with T2DM is related to lifestyle,education level and stroke.

关 键 词：认知功能障碍 2型糖尿病 相关因素 LOGISTIC回归 社区 

分 类 号：R587.1[医药卫生—内分泌] R749.1[医药卫生—内科学]