增生性瘢痕早期防治的临床现状及展望  

Clinical status and perspectives on the early management of proliferative scarring

作　　者：彭金梅 温印 聂开瑜 Peng Jinmei;Wen Yin;Nie Kaiyu(Department of Burns and Plastic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563000,China)

机构地区：[1]遵义医科大学附属医院烧伤整形外科,贵州遵义563000

出　　处：《遵义医科大学学报》2024年第12期1241-1248,共8页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:81660325);省部共建协同创新中心项目[NO:教科技厅函(2020)39];遵义医科大学研究生立项B类(NO:ZYK250)。

摘　　要：增生性瘢痕是由伤口异常愈合引起的病理性瘢痕。其特点包括持续的局部炎症和过量的胶原蛋白沉积,这可能导致外观问题、挛缩畸形、功能丧失和心理问题等。目前,关于增生性瘢痕的临床治疗手段很多,但由于其发生机制尚未完全阐明,现有的临床治疗策略虽多样,包括物理治疗、光电治疗、药物治疗以及手术治疗等,但这些方法仍未能取得令人满意的效果。目前,早期多手段的综合干预已逐渐获得大多数临床医师的共识。本综述系统回顾了针对增生性瘢痕早期防治的临床研究现状,期望为增生性瘢痕的早期综合防治提供临床证据。Objective Proliferative scarring is a pathological condition resulting from abnormal wound healing.Its characteristics include persistent local inflammation and excessive collagen deposition,which can lead to cosmetic issues,contractural deformities,functional impairment,and psychological distress.Although numerous clinical treatments for proliferative scarring are currently available,the underlying mechanisms of its formation remain inadequately understood.Consequently,existing treatment strategies,while diverse(encompassing physical therapy,phototherapy,pharmacological therapy,and surgical interventions),often fail to yield satisfactory outcomes.Recently,there has been a growing consensus among clinicians regarding the importance of early comprehensive intervention employing multiple approaches.This review systematically examines the current state of clinical studies focused on the early prevention and treatment of proliferative scarring,aiming to provide clinical evidence to support the implementation of comprehensive early prevention and treatment strategies.

关 键 词：增生性瘢痕 病理性瘢痕 早期防治 

分 类 号：R318[医药卫生—生物医学工程]