Metal-organic frameworks in oral drug delivery  

作　　者：Aun Raza Wei Wu 

机构地区：[1]Key Laboratory of Smart Drug Delivery of MOE,School of Pharmacy,Fudan University,Shanghai 201203,China [2]Center for Medical Research and Innovation,Shanghai Pudong Hospital,Fudan University Pudong Medical Center,Shanghai 201399,China [3]Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China [4]Fudan Zhangjiang Institute,Shanghai 201203,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第5期1-27,共27页亚洲药物制剂科学（英文）

摘　　要：Metal-organic frameworks(MOFs)offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination of metal ions and organic ligands.This review systematically examines the structural properties and principles of MOFs,setting the stage for their application in drug delivery.It discusses various classes of MOFs,including those based on zirconium,iron,zinc,copper,titanium,aluminum,potassium,and magnesium,assessing their drug-loading capacities,biocompatibility,and controlled release mechanisms.The effectiveness of MOFs is illustrated through case studies that highlight their capabilities in enhancing drug solubility,providing protection against the harsh gastrointestinal environment,and enabling precise drug release.The review addresses potential challenges,particularly the toxicity concerns associated with MOFs,and calls for further research into their biocompatibility and interactions with biological systems.It concludes by emphasizing the potential of MOFs in revolutionizing oral drug delivery,highlighting the critical need for comprehensive research to harness their full potential in clinical applications.

关 键 词：Metal-organic frameworks Drug delivery ORAL BIOAVAILABILITY NANOTECHNOLOGY 

分 类 号：R943[医药卫生—药剂学]