粉防己碱柔性脂质体的透皮性能和舒缓功效  

Transdermal Performance and Soothing Efficacy of Tetrandrine Flexible Liposome

作　　者：林梦感 陈丽 邓昊 谢智勇 LIN Menggan;CHEN Li;DENG Hao;XIE Zhiyong(Renhe Global(Shanghai)Big Health Research Institute Co.,Ltd.,Shanghai 200062,China)

机构地区：[1]仁和全域(上海)大健康研究院有限公司,上海200062

出　　处：《香料香精化妆品》2024年第6期63-64,65-68,共6页Flavour Fragrance Cosmetics

摘　　要：采用高压均质法制备了一种高载药量(质量分数2.0%)的粉防己碱柔性脂质体,以包封率和稳定性为指标,考察药脂比对柔性脂质体的影响。结果表明:随着药脂比的增加,脂质体的包封率均呈先增加后降低的趋势;在大豆卵磷脂、粉防己碱、胆固醇、辛酸/癸酸甘油三酯的质量比为20∶10∶1∶40的条件下制得的粉防己碱脂质体,包封率为84.5%,平均粒径为203.8 nm,PDI为0.2,Zeta电位为0.44 mV。另外,粉防己碱柔性脂质体的体外透皮试验和舒缓功效测试结果显示,粉防己碱柔性脂质体较未进行脂质体包裹的粉防己碱溶液具有更优越的透皮性能和更好的舒缓抗炎功效。The flexible liposome with high content(mass fraction 2.0%)of tetrandrine was prepared by the high pressure homogenization technique.The effects of mass ratio of tetrandrine to lecithin on entrapment efficiency and storage stability were studied.The results showed that the extent of encapsulation increased firstly and then decreased later as the increase of mass ratio of tetrandrine to lecithin.The liposomes produced with the mass ratio of lecithin,tetrandrine,cholesterol,and caprylic/capric triglyceride of 20:10:1:40 showed an encapsulation rate of 84.5%,an average particle size of 203.8 nm,a PDI of 0.2,and a zeta potential of 0.44 mV.In addition,the results of transdermal performance test and cosmetic soothing efficacy test of tetrandrine flexible liposome showed that the transdermal and soothing performance of tetrandrine flexible liposome was significantly better than that of the non-liposome-encapsulated tetrandrine solution.

关 键 词：粉防己碱 脂质体 透皮吸收 舒缓功效 

分 类 号：TQ658[化学工程—精细化工]