气相色谱法测定化妆品中去屑剂二硫化硒的含量  

Determination of Anti-dandruff Agent Selenium Disulfide in Cosmetics by Gas Chromatography

作　　者：吕稳 胡贝 李智 李丽霞 黄伟 LYU Wen;HU Bei;LI Zhi;LI Lixia;HUANG Wei(Hubei Institute for Drug Control,Wuhan 430075,Hubei,China;Hubei Engineering Research Center for Drug Quality Control,Wuhan 430075,Hubei,China)

机构地区：[1]湖北省药品监督检验研究院,湖北武汉430075 [2]湖北省药品质量检测与控制工程技术研究中心,湖北武汉430075

出　　处：《香料香精化妆品》2024年第6期129-133,共5页Flavour Fragrance Cosmetics

摘　　要：建立化妆品中二硫化硒的气相色谱检测方法。样品经三氯甲烷提取,纯净水净化后,采用超高惰性分流衬管进样,经HP-5气相色谱柱(30 m×0.32 mm×0.25μm)分离,电子捕获检测器(ECD)或火焰光度检测器(FPD)检测,外标法定量。该法在4~200μg/mL线性关系良好,使用ECD的检出限、定量限分别为0.1、0.3μg/mL,适用于定量;使用FPD的检出限为2μg/mL,适用于定性。在3个水平的加标回收率为93.85%~117.53%,相对标准偏差(RSD)为1.92%~3.14%。该方法适用于一般洗发类化妆品中二硫化硒的检测。A method for the determination of selenium disulfide in cosmetics by gas chromatography was established.The sample was extracted with chloroform and purified with purified water,and then injected into an ultra-high inert split liner.The separation was completed on an HP-5 gas chromatographic column(30 m×0.32 mm×0.25μm).The detection was accomplished by electron capture detector(ECD)or flame photometric detector(FPD),and external standard method were applied for quantitative analysis.The method showed good linearity in the range of 4-200μg/mL.The limits of detection and quantification were 0.1 and 0.3μg/mL for ECD,which was suitable for quantification.The limits of detection using FPD were 2μg/mL,which was suitable for qualification.The spiked recoveries at 3 levels were 93.85%-117.53%,with the relative standard deviations(RSDs)of 1.92%-3.14%.This method is applicable to the determination of selenium disulfide in general shampoo cosmetics.

关 键 词：化妆品 二硫化硒 气相色谱法 去屑剂 

分 类 号：TQ658[化学工程—精细化工] O657.71[理学—分析化学]