西藏地区原发性高血压合并高尿酸血症患者发病情况及影响因素研究  

A Study on the Prevalence and Influencing Factors of Primary Hypertension Complicated with Hyperuricemia in the Tibet Region

作　　者：秦珊珊 高寒 任海龙[1] 张宇鹏 旦增顿珠[1] QIN Shanshan;GAO Han;REN Hailong;ZHANG Yupeng;Danzeng-Dunzhu(School of Medical,Tibet University,Lhasa 850000,Chian;Qilu Medical University School of Stomatology,Zibo 255000,China)

机构地区：[1]西藏大学医学院,西藏拉萨850000 [2]齐鲁医药学院口腔医学院,山东淄博255000

出　　处：《高原科学研究》2024年第4期90-98,共9页Plateau Science Research

基　　金：西藏自治区自然科学基金重点项目(XZ202201ZR0036G);西藏大学研究生高层次人才培养计划项目(2022-GSP-S114)。

摘　　要：目的:探讨西藏地区高血压患者高尿酸血症(hyperuricemia,HUA)发病情况及影响因素。方法:回顾分析2018年1月至12月在西藏自治区某三甲医院心血管内科收治的高血压患者301例,按是否合并高尿酸血症分为非HUA组(117例)和HUA组(184例),收集两组患者的人口学、合并病史、体格检查、生化指标等指标进行比较,采用多因素Logistic回归分析探讨HUA和高血压患者之间的关系。结果:西藏地区高血压人群HUA的患病率为61.0%(184/301),其中男132例(71.7%)、女52例(28.3%),藏族74例(40.2%)、汉族110例(59.8%),差异有统计学意义(P<0.05)。汉族(OR=5.720,95%CI:2.174~15.048)、饮酒(OR=3.165,95%CI:1.331~7.525)、肥胖(OR=2.977,95%CI:1.157~7.664)、血红蛋白(HB)偏高(OR=3.069,95%CI:1.202~7.836)、高甘油三酯血症(OR=2.466,95%CI:1.065~5.707)、高密度脂蛋白胆固醇(HDL-C)偏低(OR=2.610,95%CI:1.147~5.939)、利尿剂(OR=3.221,95%CI:1.444~7.187)、尿素(OR=1.649,95%CI:1.251~2.173)、血肌酐(SCR)(OR=1.039,95%CI:1.013~1.065)为高血压患HUA危险因素,女性(OR=0.444,95%CI:0.199~0.988)为保护因素。结论:西藏地区高血压HUA患病率较高,HUA患者以男性和汉族为主。肥胖、饮酒、HB偏高、肌酐异常、尿素氮异常、高甘油三酯血症、高密度脂蛋白偏低,利尿剂药物使用可能是高血压患者发生HUA的危险因素。Objective:To explore the prevalence and influencing factors of hyperuricemia(HUA)in hypertensive patients in the Tibet region.Methods:A retrospective analysis was conducted on 301 hypertensive patients ad-mitted to the cardiology department of a tertiary hospital in the Tibet Autonomous Region from January to Decem-ber 2018.Patients were divided into two groups based on the presence of hyperuricemia:the non-HUA group(117 cases)and the HUA group(184 cases).Demographic data,comorbidities,physical examinations,and bio-chemical indicators of the two groups were collected and compared.Multifactorial Logistic regression analysis was used to explore the relationship between HUA and hypertensive patients.Results:The prevalence of HUA in the hypertensive population in Tibet was 61%(184/301),including 132(71.7%)males and 52(28.3%)fe-males,74(40.2%)Tibetans and 110(59.8%)Han nationality,with statistically significant differences(P<0.05).Han Chinese(OR=5.720,95%CI:2.174∼15.048),alcohol consumption(OR=3.165,95%CI:1.331∼7.525),obesity(OR=2.977,95%CI:1.157∼7.664),high HB(OR=3.069,95%CI:1.202∼7.836),hypertriglyceridemia(OR=2.466,95%CI:1.065∼5.707),low HDL-C(OR=2.610,95%CI:1.147∼5.939),diuretics(OR=3.221,95%CI:1.444∼7.187),urea(OR=1.649,95%CI:1.251∼2.173),and SCR(OR=1.039,95%CI:1.013∼1.065)were risk factors for developing HUA in hypertension,and women(OR=0.444,95%CI:0.199∼0.988)were protective factors.Conclusion:The prevalence of hypertensive HUA is high in Tibet,and HUA patients are predominantly male and Han nationality.Obesity,alcohol consumption,high HB,abnormal creatinine,abnor-mal urea nitrogen,hypertriglyceridemia,low HDL,and diuretic drug use may be risk factors for HUA in hyper-tensive patients.

关 键 词：西藏地区 高血压 高尿酸血症 影响因素 

分 类 号：R544.1[医药卫生—心血管疾病]