氧化应激对母畜子宫及妊娠影响的研究进展  

Research Progress in the Effect of Oxidative Stress on Uterus and Pregnancy in Female Livestock

作　　者：孟亚轩 刘彦[2,3] 韦兴茹[4] 陈国顺 冯涛[1,2,3] MENG Yaxuan;LIU Yan;WEI Xingru;CHEN Guoshun;FENG Tao(College of Animal Science and Technology,Gansu Agricultural University,Lanzhou 730070,China;Institute of Animal Husbandry and Veterinary Medicine(IAHVM),Beijing Academy of Agriculture and Forestry Sciences(BAAFS),Beijing 100097,China;Joint Laboratory of Animal Science between IAHVM of BAAFS and Division of Agricultural Science and Natural Resource of Oklahoma State University,Beijing 100097,China;Beijing Feed Industry Association,Beijing 100107,China)

机构地区：[1]甘肃农业大学动物科学技术学院,兰州730070 [2]北京市农林科学院畜牧兽医研究所,北京100097 [3]北京市农林科学院-美国俄克拉荷马州立大学动物科学联合实验室,北京100097 [4]北京市饲料工业协会,北京100107

出　　处：《畜牧兽医学报》2024年第12期5368-5378,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31972575);北京市农林科学院课题(CZZJ202205)。

摘　　要：氧化应激是细胞内外环境变化导致产生过多活性氧的状态,在调控子宫功能中发挥着重要作用。近年来,研究表明氧化应激可以通过影响子宫内生殖激素、免疫反应、调节子宫环境和细胞信号传导等途径调控母畜子宫功能。此外,过度氧化应激会损害母体和胎盘功能,与子宫内膜癌、先兆子痫、妊娠期糖尿病和宫内生长受限等生殖疾病的形成关系密切。本文综述了近年来关于氧化应激调控母畜子宫功能的研究进展,旨在深入了解氧化应激对母畜子宫功能的影响,为提高母畜繁殖效率提供理论指导和实践应用。Oxidative stress is a state of excessive reactive oxygen species produced by changes of intracellular and extracellular environment,which plays an important role in the regulation of uterine function.In recent years,studies have shown that oxidative stress can regulate the function of the uterus by affecting reproductive hormones,immune responses,regulating uterine environment and cell signaling.In addition,excessive oxidative stress can impair maternal and placental function,closely related to reproductive diseases such as endometrial carcinoma,pre-eclampsia,gestational diabetes mellitus,and intrauterine growth retardation.This paper reviewed the research progress on the regulation of oxidative stress on the uterine function of female livestock in recent years,in order to better understanding the effect of oxidative stress on the uterine function of female animals,providing new theoretical guidance and practical application for improving the reproduction efficiency of female livestock.

关 键 词：氧化应激 母畜 子宫 激素 炎症 生殖疾病 

分 类 号：S814.1[农业科学—畜牧学]