肢体成角畸形马驹及其母马的血液生理生化、炎性因子和激素变化研究  

The Changes of Blood Physio-biochemistry,Inflammatory and Hormone Factors in the Angular Limb Deformity Foals and Their Mares

作　　者：刘义钢 马玉辉 冯琦 马雪连 李娜[1] 孙亚伟[1] 于维浩 姚刚[1] LIU Yigang;MA Yuhui;FENG Qi;MA Xuelian;LI Na;SUN Yawei;YU Weihao;YAO Gang(College of Veterinary Medicine,Xinjiang Agricultural University,Urumqi 830052,China;Xiyu Horse Industry Co.,Ltd.,of Zhaosu County,Ili Kazakh Autonomous Prefecture,Zhaosu 835099,China;Autonomous Postdoctoral Practice Base of Zhaosu West Horse Industry Co.,Ltd.,Zhaosu 835099,China;Zhaosu County Horse Farm,Ili Kazakh Autonomous Prefecture,Zhaosu 835099,China)

机构地区：[1]新疆农业大学动物医学学院,乌鲁木齐830052 [2]新疆伊犁哈萨克自治州昭苏县西域马业有限责任公司,昭苏835099 [3]昭苏县西域马业有限责任公司自治区级博士后实践基地,昭苏835099 [4]新疆伊犁哈萨克自治州昭苏县马场,昭苏835099

出　　处：《畜牧兽医学报》2024年第12期5854-5865,共12页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：新疆维吾尔自治区“天池英才”引进计划(ZYYD2022013)。

摘　　要：本研究旨在调查罹患肢体成角畸形(angular limb deformities,ALDs)的新生马驹发病率,在此基础上对ALDs马驹及其母马的血液生理生化、炎性因子和激素指标与肢体正常马驹及其母马进行比较研究。在新疆伊犁昭苏县对460匹2~28日龄的新生马驹进行临床调查和诊断,通过形态检查和影像学检查,诊断筛查ALDs马驹和其母马。以肢体正常马驹及其母马作为对照,测定其血液生理指标、生化指标、炎性因子和激素含量。临床调查发现肢体异常马驹30匹,占所调查马驹的6.52%。确诊罹患ALDs马驹16匹,占肢体异常马驹总数的53%,ALDs的发病率为3.48%。ALDs马驹的单核细胞、嗜酸性粒细胞显著高于正常马驹,ALDs母马的平均红细胞体积、平均红细胞血红蛋白含量显著高于正常母马。ALDs马驹的血钙、血磷、血糖、肌酐、镁水平显著低于正常马驹,而碱性磷酸酶、总蛋白、白蛋白显著高于正常马驹;ALDs母马的血钙、血磷、血糖、总胆红素、甘油三酯、总胆固醇、镁水平显著低于正常母马,而天门冬氨酸氨基转移酶、碱性磷酸酶、白蛋白显著高于正常母马。ALDs母马的肿瘤坏死因子、白细胞介素6水平显著高于正常母马,而白细胞介素10水平显著低于正常母马。ALDs马驹的甲状旁腺激素、1,25-二羟基维生素D3水平显著高于正常马驹。其余指标无显著变化。本研究探明了新疆伊犁昭苏县新生马驹的ALDs发病率现状。结果提示,ALDs马驹及其母马在钙磷代谢、血脂水平以及特定激素水平与正常对照组的显著差异变化与新生马驹骨骼发育异常及ALDs的发生密切相关。本研究为揭示ALDs的病因提供了血液生理生化数据支撑,对ALDs的早期辅助诊断具有重要临床参考价值。The aim of the study is to investigate the incidence rate of Angular Limb Deformities(ALDs)in newborn foals,to compare the differences of blood physio-biochemistry,the inflammatory factors and the hormones in ALDs foals and their mares with the normal counterparts.Four hundred and sixty newborn foals at the age of 2-28 days were clinically surveyed,the ALDs foals were diagnosed by clinical observation combined with the X-ray imaging.The blood physio-biochemical indices,the inflammatory factors,and the hormones in ALDs foals and their mares were measured in the comparison with those in their normal counterparts.The results showed that 30 newborn foals were found with limb abnormalities,accounting for 6.52%of all investigated foals,in which 16 foals were diagnosed as ALD suffers,and accounting for 53%of all limb abnormality foals.The incidence rate of ALDs was 3.48%.The monocytes and eosinophils of ALDs foals were significantly higher than those of normal foals,and the average red blood cell volume and average red blood cell hemoglobin content of ALDs mares were significantly higher than those of normal mares.The blood calcium,blood phosphorus,blood glucose,creatinine,and magnesium levels of ALDs foals were significantly lower than those of normal foals,while alkaline phosphatase,total protein,and albumin were significantly higher than those of normal foals;the blood calcium,Serum phosphorus,blood sugar,total bilirubin,triglycerides,total cholesterol,and magnesium levels were significantly lower than those of normal mares,while aspartate aminotransferase,alkaline phosphatase,and albumin were significantly higher than those of normal mares.The levels of tumor necrosis factor and interleukin 6 in ALDs mares were significantly higher than those in normal mares,while the levels of interleukin 10 were significantly lower than those in normal mares.The levels of parathyroid hormone and 1,25-dihydroxyvitamin D3 in ALDs foals were significantly higher than those in normal foals.There were no significant changes in the rema

关 键 词：新生马驹 肢体成角畸形 血液生理生化 炎性因子 激素 

分 类 号：S857.31[农业科学—临床兽医学]