中性粒细胞/淋巴细胞比率和单核/高密度脂蛋白胆固醇比率在突发性耳聋患者中的表达水平及与预后的相关性  

Expression level of neutrophil/lymphocyte ratio and monocyte/high density lipoprotein cholesterol ratio in patients with sudden deafness and their correlation with prognosis

作　　者：朱红美 黄永久 储九圣 庞秀红 ZHU Hongmei;HUANG Yongjiu;CHU Jiusheng;PANG Xiuhong(Department of Otorhinolaryngology Head and Neck Surgery,Nanjing Medical University Affiliated Taizhou People′s Hospital,Taizhou 225300,Jiangsu,China)

机构地区：[1]南京医科大学附属泰州人民医院耳鼻喉头颈外科,江苏泰州225300

出　　处：《实用医学杂志》2024年第24期3503-3508,共6页The Journal of Practical Medicine

基　　金：江苏省卫生健康委科研课题(编号:M2022067);泰州市科技支撑(社会发展)项目(编号:TS202214)。

摘　　要：目的探索中性粒细胞/淋巴细胞比率(NLR)和单核/高密度脂蛋白胆固醇比率(MHR)与突发性耳聋(SSNHL)发病及预后的相关性。方法选取2022年1月至2024年5月于医院治疗的138例突发性耳聋病患者为研究组,另选取116例正常健康体检者为对照组,比较两组及不同分型SSNHL患者NLR及MHR的变化。采用logistic回归探讨SSNHL患者预后影响因素。结果研究组NLR和MHR显著高于对照组(P<0.05)。不同分型SSNHL患者平均听阈、总胆固醇(TC)、纤维蛋白原(FIB)、血小板计数(PLT)、皮质醇(COR)、NLR、MHR差异有统计学意义(P<0.05)。NLR、MHR和SSNHL呈现显著相关性(P<0.05),NLR和MHR增高是SSNHL患者预后不良的危险因素。结论NLR和MHR与SSNHL的发病关系密切,是导致SSNHL患者预后不良的重要因素。Objective To explore the correlation between neutrophil/lymphocyte ratio(NLR)and monocyte/high density lipoprotein cholesterol ratio(MHR)and the onset and prognosis of sudden deafness(SSNHL).Methods 138 patients with sudden deafness who were treated in the hospital from January 2022 to May 2024 were selected as the study group,and 116 normal healthy people were selected as the control group.The changes of NLR and MHR in two groups and different types of SSNHL patients were compared.Logistic regression was used to explore the prognostic factors of patients with SSNHL.Results NLR and MHR in the study group were significantly higher than those in the control group(P<0.05).There were statistical differences in the average hearing threshold,total cholesterol(TC),fibrinogen(FIB),platelet count(PLT),cortisol(COR),NLR and MHR in patients with different types of SSNHL(P<0.05).NLR,MHR and SSNHL were significantly correlated(P<0.05).The increase of NLR and MHR is a risk factor for poor prognosis in patients with SSNHL.Conclusion NLR and MHR are closely related to the pathogenesis of SSNHL and are important factors leading to poor prognosis of patients with SSNHL.

关 键 词：中性粒细胞/淋巴细胞比率 单核/高密度脂蛋白胆固醇比率 突发性耳聋发病 预后 相关性分析 

分 类 号：R764[医药卫生—耳鼻咽喉科] R446.11[医药卫生—临床医学]