血清sICAM-1联合SII指数对类风湿关节炎患者疾病活动度的预测价值分析  

Analysis of the Predictive Value of Serum sICAM-1 Combined with SII Index for Disease Activity in Patients with Rheumatoid Arthritis

作　　者：张艳 袁晓玲 张亚兵 ZHANG Yan;YUAN Xiaoling;ZHANG Yabing(Department of Rheumatology and Immunology,Zhangjiagang Hospital Affiliated to Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属张家港医院风湿免疫科,江苏苏州215000

出　　处：《反射疗法与康复医学》2024年第14期75-78,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的分析血清可溶性细胞间黏附分子-1(血清sICAM-1)联合系统性免疫性炎症(SII)指数对类风湿关节炎(RA)患者疾病活动度的预测价值。方法选取2022年1月—2024年2月苏州大学附属张家港医院收治的102例RA患者为研究对象,根据疾病活动度28(DAS28)评分将其分为活动组(n=77)和缓解组(n=25)。比较两组的血清sICAM-1、SII指数,采用logistic回归分析影响RA患者疾病活动度的因素,绘制受试者工作特征曲线计算血清sICAM-1联合SII指数对RA患者疾病活动度的预测效能。结果活动组血清sICAM-1、SII指数均高于缓解组,组间差异有统计学意义(P<0.05)。logistic回归分析显示,关节肿胀数(TJC)、关节压痛数(SJC)、细胞沉降率(ESR)、血小板计数、血清sICAM-1、SII指数是RA患者疾病处于活动期的危险因素,差异有统计学意义(P<0.05)。ROC曲线显示,血清sICAM-1、SII指数联合预测RA患者疾病活动度的曲线下面积(AUC)为0.926,高于单独预测的0.877、0.803。结论血清sICAM-1联合SII指数对RA疾病活动度的预测价值较高,可为RA的临床治疗提供参考。Objective To analyze the predictive value of serum soluble intercellular adhesion molecule-1(serum sICAM-1)combined with systemic immune inflammation(SII)index for disease activity in patients with rheumatoid arthritis(RA).Methods A total of 102 RA patients admitted to Zhangjiagang Hospital Affiliated to Soochow University from January 2022 to February 2024 were selected as the research objects,according to disease activity score 28(DAS28)score,they were divided into a active group(n=77)and a remission group(n=25).The serum sICAM-1 and SII indexes of the two groups were compared.The Receiver Operating Characteristic(ROC)curve was drawn to calculate the predictive efficacy of serum sICAM-1 combined with SII index for disease activity in RA patients.Results The sICAM-1 and SII indexes in the active group were higher than those in the remission group,and the difference between the two groups was statistically significant(P<0.05).Logistic regression analysis showed that the number of swollen joints(TJC),the number of tender joints(SJC),erythrocyte sedimentation rate(ESR),platelet count,serum sICAM-1 and SII indexes were risk factors for RA patients in the active stage and the difference was statistically significant(P<0.05).ROC curve showed that the Area Under the Curve(AUC)of serum sICAM-1 and SII index combined to predict disease activity in RA patients was 0.926,which was higher than 0.877 and 0.803 predicted alone.Conclusion Serum sICAM-1 combined with SII index has a high predictive value for RA disease activity,which can provide a reference for clinical treatment of RA.

关 键 词：类风湿关节炎 系统性免疫性炎症指数 血清可溶性细胞间黏附分子-1 疾病活动度 

分 类 号：R593.22[医药卫生—内科学]