依帕司他联合康柏西普治疗对糖尿病视网膜病变患者视网膜血流动力学和视力的影响  

Effect of Epalrestat Combined with Conbercept on Retinal Hemodynamics and Visual Acuity in Patients with Diabetic Retinopathy

作　　者：严勋 Yan Xun(Department of Endocrinology,The Fourth People's Hospital of Jiangyou City,Mianyang 621702,China)

机构地区：[1]江油市第四人民医院内分泌科,四川绵阳621702

出　　处：《反射疗法与康复医学》2024年第14期87-91,共5页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨依帕司他联合康柏西普治疗对糖尿病视网膜病变患者视网膜血流动力学和视力的影响。方法选择2022年5月—2023年9月江油市第四人民医院收治的98例糖尿病视网膜病变患者为研究对象,按随机数字表法将其分为对照组和观察组,各49例。对照组采用康柏西普治疗,观察组在对照组基础上联合依帕司他治疗,两组均治疗1个疗程。比较两组的临床疗效、视网膜血流动力学指标、视力、视网膜损伤情况和不良反应发生情况。结果观察组治疗总有效率为97.96%,高于对照组的85.71%,差异有统计学意义(P<0.05)。治疗后,观察组视网膜中央动脉、视网膜中央静脉的收缩期峰值流速、舒张末期血流速均快于对照组,动脉阻力指数低于对照组,组间差异有统计学意义(P<0.05);观察组视网膜渗漏面积、毛细血管无灌注区面积均小于对照组,组间差异有统计学意义(P<0.05);治疗后1、3、6个月,观察组视力均高于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论糖尿病视网膜病变应用依帕司他联合康柏西普治疗,能改善患者的视网膜血流动力学指标,提升视力,缓解视网膜损伤情况,临床疗效好,且安全性高,值得应用。Objective To investigate the effects of epalrestat combined with conbercept on retinal hemodynamics and visual acuity in patients with diabetic retinopathy.Methods Ninety-eight patients with diabetic retinopathy admitted to the Fourth People's Hospital of Jiangyou City from May 2022 to September 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 49 cases in each group.The control group was treated with conbercept,and the observation group was treated with epalrestat on the basis of the control group,both groups received 1 course of treatment.The clinical efficacy,retinal hemodynamics indicators,visual acuity,retinal injury and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.96%,which was higher than 85.71% of the control group,and the difference was statistically significant(P<0.05).After treatment,the peak systolic flow velocity and end-diastolic blood flow velocity of central retinal artery and central retinal vein in observation group were faster than those in control group,and the arterial resistance index was lower than that in control group,and the difference between the groups were statistical significance(P<0.05);the area of retinal leakage and non-perfusion area of capillary in the observation group were smaller than those in the control group,and the difference between the groups were statistically significant(P<0.05);at 1,3 and 6 months after treatment,the visual acuity of observation group were higher than those of control group,and the difference between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of diabetic retinopathy with epalrestat combined with conbercept can improve the retinal hemodynamics indicators of patients,improve visual acuity,and alleviate retinal damage.The clinic

关 键 词：糖尿病视网膜病变 康柏西普 依帕司他 视网膜血流动力学指标 视力 

分 类 号：R587.1[医药卫生—内分泌]