PCT、PA、CRP及WBC联合检测对儿童感染性疾病的诊断价值分析  

The value of combined detection of PCT,PA,CRP and WBC in the diagnosis of infectious diseases in children

作　　者：林琴 LIN Qin(Inspection Department,Pingtan Comprehensive Experimental Zone Haitan Street Community Health Service Center,Fuzhou 350400,China)

机构地区：[1]平潭综合实验区海坛街道社区卫生服务中心检验科,350400

出　　处：《中国现代药物应用》2024年第23期67-70,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析降钙素原(PCT)、前白蛋白(PA)、C反应蛋白(CRP)及白细胞计数(WBC)联合检测对儿童感染性疾病的诊断价值。方法纳入97例感染性疾病患儿,根据病原学检查的最终结果分为细菌性感染组(46例)和非细菌性感染组(51例);另选取身体健康的体检儿童50例作为对照组。检测并比较三组PCT、PA、CRP、WBC水平及阳性率;分析PCT、PA、CRP、WBC单独检测及联合检测对细菌性感染的诊断结果;比较PCT、PA、CRP、WBC单独检测及联合检测对细菌性感染的诊断效能。结果细菌性感染组的PCT(4.56±1.03)ng/ml、CRP(92.64±48.71)mg/L及WBC(16.37±4.15)×10^(9)/L均高于非细菌性感染组的(0.44±0.14)ng/ml、(7.53±2.61)mg/L、(9.16±3.68)×10^(9)/L和对照组的(0.39±0.11)ng/ml、(6.70±2.19)mg/L、(6.82±2.88)×10^(9)/L,PA(102.60±24.43)mg/L低于非细菌性感染组的(252.24±45.43)mg/L和对照组的(265.69±82.24)mg/L(P<0.05);非细菌性感染组的WBC显著高于对照组(P<0.05);对照组与非细菌性感染组的PCT、CRP及PA比较无差异(P>0.05)。细菌性感染组的PCT、PA、CRP和WBC阳性率均高于非细菌性感染组和对照组(P<0.05);非细菌性感染组的PCT、PA、CRP和WBC阳性率与对照组比较无差异(P>0.05)。联合检测的灵敏度、特异度、阳性预测值及阴性预测值分别为93.48%、92.16%、91.49%、94.00%,PCT单独检测分别为69.57%、76.47%、72.73%、73.58%,PA单独检测分别为65.22%、74.51%、69.77%、70.37%,CRP单独检测分别为60.87%、76.47%、70.00%、68.42%,WBC单独检测分别为52.17%、72.55%、63.16%、62.71%;联合检测的灵敏度、特异度、阳性预测值及阴性预测值均高于PCT、PA、CRP、WBC单独检测(P<0.05)。结论PCT、PA、CRP及WBC联合检测有利于诊断儿童细菌性感染,能明显提升诊断效能,可用于指导抗菌药物的使用。Objective To analyze the diagnostic value of combined detection of procalcitonin(PCT),prealbumin(PA),C-reactive protein(CRP)and white blood cell count(WBC)in children with infectious diseases.Methods 97 children with infectious diseases were included as the study subjects.According to the pathogenic results,they were divided into bacterial infection group(46 cases)and non-bacterial infection group(51 cases),and another 50 healthy children were selected as the control group.The PCT,PA,CRP,and WBC levels and positive rates of the three groups were tested and compared;the diagnostic results of individual and combined detection of PCT,PA,CRP and WBC for bacterial infections were analyzed;the diagnostic efficacy of individual and combined detection of PCT,PA,CRP,and WBC were compared.Results The bacterial infection group had PCT of(4.56±1.03)ng/ml,CRP of(92.64±48.71)mg/L and WBC of(16.37±4.15)×10^(9)/L,which were all higher than(0.44±0.14)ng/ml,(7.53±2.61)mg/L and(9.16±3.68)×10^(9)/L in the non-bacterial infection group,and(0.39±0.11)ng/ml,(6.70±2.19)mg/L and(6.82±2.88)×10^(9)/L in the control group;the bacterial infection group had lower PA of(102.60±24.43)mg/L than(252.24±45.43)mg/L in the non-bacterial infection group,and(265.69±82.24)mg/L in the control group(P<0.05).WBC in the non-bacterial infection group was significantly higher than that in the control group(P<0.05).There was no difference in the comparison of PCT,CRP and PA between the control group and the non-bacterial infection group(P>0.05).The positive rates of PCT,PA,CRP and WBC in the bacterial infection group were higher than those in the non-bacterial infection group and the control group(P<0.05).The positive rates of PCT,PA,CRP and WBC in the non-bacterial infection group were not different from those in the control group(P>0.05).The sensitivity,specificity,positive predictive value and negative predictive value of combined detection were 93.48%,92.16%,91.49%and 94.00%,those of PCT alone were 69.57%,76.47%,72.73%,73.58%,those of PA al

关 键 词：儿童 感染性疾病 前白蛋白 降钙素原 C反应蛋白 白细胞计数 诊断 

分 类 号：R725.1[医药卫生—儿科]