贝那普利与硝苯地平联合治疗老年高血压性心脏病患者的临床价值探讨  

Clinical value of benazepril combined with nifedipine in the treatment of elderly patients with hypertensive heart disease

作　　者：荀山英 XUN Shan-ying(General Department,Community Health Service Center,Xingbin Street,Jimei District,Xiamen 361022,China)

机构地区：[1]厦门市集美区杏滨街道社区卫生服务中心全科,361022

出　　处：《中国现代药物应用》2024年第23期91-94,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析在老年高血压性心脏病(HHD)治疗中采取贝那普利与硝苯地平联合治疗的临床价值。方法将50例老年HHD患者作为观察对象,以随机数字表法分为观察组(25例)及对照组(25例)。对照组在常规治疗的基础上给予硝苯地平治疗,观察组在对照组的基础上联合贝那普利治疗。比较两组临床疗效,治疗前后的心功能指标[左室舒张末期内径(LVEDd)、左室舒张早期/晚期峰值流速比值(E/A)、左室射血分数(LVEF)]及运动能力指标[代谢当量(METs)、每千克体质量最大耗氧量(VO_(2)max)、6 min步行试验距离(6MWD)]水平。结果观察组总有效率92.0%高于对照组的68.0%,有统计学差异(P<0.05)。治疗后,两组LVEDd小于治疗前,E/A、LVEF高于治疗前,且观察组LVEDd(52.36±3.16)mm小于对照组的(55.85±2.48)mm,E/A(1.11±0.04)、LVEF(53.69±2.64)%高于对照组的(0.89±0.08)、(48.52±1.94)%,有统计学差异(P<0.05)。治疗后,两组METs、VO_(2)max高于治疗前,6MWD长于治疗前,且观察组METs(5.49±0.32)、VO_(2)max(24.58±2.64)ml/(kg·min)高于对照组的(4.78±0.24)、(19.55±2.64)ml/(kg·min),6MWD(295.62±15.84)m长于对照组的(245.63±13.85)m,有统计学差异(P<0.05)。结论老年HHD患者在常规治疗的基础上给予贝那普利联合硝苯地平治疗具有较高的治疗效果,有助于提高患者的心功能与运动能力,较常规治疗措施更有助于患者治疗后康复,值得推广应用。Objective To analyze the clinical value of benazepril combined with nifedipine in the treatment of elderly patients with hypertensive heart disease(HHD).Methods 50 elderly patients with HHD as observation subjects were divided into an observation group(25 cases)and a control group(25 cases)by random number table method.The control group was treated with nifedipine on the basis of conventional treatment,and the observation group was treated with benazepril on the basis of the control group.Both groups were compared in terms of clinical efficacy,cardiac function indicators[left ventricular end-diastolic diameter(LVEDd),ratio of early transmitral flow velocity to later transmitral flow velocity(E/A),left ventricular ejection fraction(LVEF)]and exercise capacity indicators[metabolic equivalents(METs),maximal oxygen consumption(VO_(2)max),6-min walking distance(6MWD)]before and after treatment.Results The total effective rate of 92.0%in the observation group was higher than 68.0%in the control group,and there was statistical difference(P<0.05).After treatment,LVEDd in both groups was lower than that before treatment,and E/A and LVEF were higher than those before treatment;LVEDd of(52.36±3.16)mm in the observation group was smaller than(55.85±2.48)mm in the control group;the observation group had E/A of(1.11±0.04)and LVEF of(53.69±2.64)%,which were higher than(0.89±0.08)and(48.52±1.94)%in the control group;there was statistical difference(P<0.05).After treatment,METs and VO_(2)max in both groups were higher than those before treatment,and 6MWD was longer than that before treatment;the observation group had METs of(5.49±0.32)and VO_(2)max of(24.58±2.64)ml/(kg·min),which were higher than(4.78±0.24)and(19.55±2.64)ml/(kg·min)in the control group;6MWD of(295.62±15.84)m in the observation group was longer than(245.63±13.85)m in the control group;there was statistical difference(P<0.05).Conclusion In elderly patients with HHD,the combination of benazepril and nifedipine on the basis of conventional treatment has

关 键 词：贝那普利 硝苯地平 高血压性心脏病 老年 

分 类 号：R541.3[医药卫生—心血管疾病]