卡贝缩宫素预防高危孕产妇阴道分娩产后出血的应用效果分析  

Analysis of the application effect of carbetocin in preventing postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery

作　　者：郑惠芬 ZHENG Hui-fen(Obstetrics and Gynecology Department,Songshan Health Hospital of Luoyuan County,Fuzhou 350601,China)

机构地区：[1]福建省罗源县松山卫生院妇产科,350601

出　　处：《中国现代药物应用》2024年第23期104-107,共4页Chinese Journal of Modern Drug Application

摘　　要：目的全面评估在阴道分娩中应用卡贝缩宫素预防高危孕产妇阴道分娩产后出血的应用效果。方法100例阴道分娩高危孕产妇,通过随机数表法分成对照组与观察组,每组50例。对照组采用缩宫素治疗,观察组采用卡贝缩宫素治疗。比较两组的第三产程用时、产后2、24 h出血量、凝血功能指标、红细胞下降值、血红蛋白下降值、产后血压与心率,产后出血、不良反应发生率及需要其他方式治疗占比。结果观察组的第三产程用时(8.16±0.85)min较对照组的(9.63±0.96)min更短,产后2 h出血量(190.48±56.11)ml、产后24 h出血量(265.48±68.61)ml较对照组的(232.49±69.93)、(342.00±75.56)ml更少(P<0.05)。观察组产后凝血酶原时间(PT)(11.58±2.31)s、活化部分凝血活酶时间(APTT)(28.96±3.84)s短于对照组的(13.06±2.03)、(33.24±3.85)s,纤维蛋白原(FIB)(3.69±0.84)g/L高于对照组的(3.25±0.37)g/L(P<0.05);观察组产后红细胞下降值(0.41±0.05)×10^(12)/L、血红蛋白下降值(6.52±1.43)g/L低于对照组的(0.63±0.10)×10^(12)/L、(8.73±1.69)g/L(P<0.05)。两组产后收缩压、舒张压水平差异不显著(P>0.05);观察组产后心率(86.19±2.67)次/min低于对照组的(92.59±2.55)次/min(P<0.05)。两组均未发生产后出血;两组不良反应发生率差异不显著(P>0.05);观察组需要其他方式治疗占比10%低于对照组的28%(P<0.05)。结论在阴道分娩高危孕产妇中使用卡贝缩宫素具有积极意义,能够有效改善产后出血情况,优化分娩进展,从而改善预后,值得临床推广应用。Objective To comprehensively evaluate the application effect of carbetocin in preventing postpartum hemorrhage in high-risk pregnant women undergoing vaginal delivery.Methods 100 high-risk women with vaginal delivery were divided into a control group and an observation group using a random numerical table,each consisting of 50 cases.The control group was treated with oxytocin,and the observation group was treated with carbetocin.Comparison was made on the duration of the third stage of labor,bleeding volume at 2 and 24 h postpartum,coagulation function indicators,decline in red blood cell and hemoglobin,postpartum blood pressure and heart rate,incidence of postpartum hemorrhage and adverse reactions between the two groups.Results The duration of the third stage of labor of(8.16±0.85)min in the observation group was shorter than(9.63±0.96)min in the control group;the observation group had bleeding volume of(190.48±56.11)ml at 2 h postpartum and(265.48±68.61)ml at 24 h postpartum,which were less than(232.49±69.93)and(342.00±75.56)ml in the control group(P<0.05).The observation group had postpartum prothrombin time(PT)of(11.58±2.31)s and activated partial thromboplastin time(APTT)of(28.96±3.84)s,which were shorter than(13.06±2.03)and(33.24±3.85)s in the control group;the fibrinogen(FIB)of(3.69±0.84)g/L in the observation group was higher than(3.25±0.37)g/L in the control group(P<0.05).The decline in red blood cell of the observation group was(0.41±0.05)×10^(12)/L and the decline in hemoglobin was(6.52±1.43)g/L,which were lower than(0.63±0.10)×10^(12)/L and(8.73±1.69)g/L of the control group(P<0.05).There were no significant differences in postpartum systolic blood pressure and diastolic blood pressure between the two groups(P>0.05).The postpartum heart rate of(86.19±2.67)beats/min in the observation group was lower than(92.59±2.55)beats/min in the control group(P<0.05).No postpartum hemorrhage occurred in both groups.There was no significant difference in the incidence of adverse reactions betwee

关 键 词：卡贝缩宫素 缩宫素 阴道分娩 产后出血 不良反应 

分 类 号：R714.461[医药卫生—妇产科学]