紫丁香叶化学成分研究  

Chemical constituents of Syringa oblata leaves

作　　者：冯小涛 孙延平[1] 黎冠兰 王知斌[1] 杨炳友[1] 匡海学[1] FENG Xiao-tao;SUN Yan-ping;LI Guan-lan;WANG Zhi-bin;YANG Bing-you;KUANG Hai-xue(Heilongjiang University of Chinese Medicine,Key Laboratory of Basic and Applied Research in North Medicine,Commission Education,Heilongjiang Key Laboratory of Drug Efficacy Material of Traditional Chinese Medicine and Natural Product,Harbin 150040)

机构地区：[1]黑龙江中医药大学,教育部北药基础与应用研究重点实验室,黑龙江省中药及天然药物药效物质基础研究重点实验室,哈尔滨150040

出　　处：《中南药学》2024年第12期3206-3214,共9页Central South Pharmacy

基　　金：中药传承与创新“百千万”人才工程——岐黄工程首席科学家项目(国中医药人教函[2021]7号);2022年全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号);第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号)。

摘　　要：目的 研究紫丁香叶的化学成分。方法 运用硅胶、ODS等柱色谱方法及制备型高效液相色谱等技术对紫丁香叶进行系统的提取分离,采用NMR、MS等技术综合解析鉴定化学成分的结构。结果 从紫丁香叶中共分离得到19个化合物,分别鉴定为syringalactone B(1)、(8E)-ligstroside(2)、(8E)-女贞子苷(3)、hydroxyframoside(4)、fraxiformoside(5)、oleoacteoside(6)、丁香苦苷(7)、tetracentronside B(8)、(+)松脂酚-4-O-β-D-吡喃葡萄糖苷(9)、4,4'-dimethoxy-3'-hydroxy-7,9':7',9-diepoxylignan-3-O-β-D-glucopyranoside(10)、lariciresinol-4'-O-β-D-glucopyranoside(11)、olivil-4'-O-β-D-glucopyranoside(12)、isolariciresinol-4-O-β-D-glucopyranoside(13)、紫丁香苷(14)、松柏苷(15)、(4ξ)-α-terpineol 8-O-[α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside](16)、(Z)-3-hexenyl β-D-glucopyranoside(17)、苯甲醇-β-巢菜糖苷(18)、冬绿苷(19)。结论 化合物5、10、15、16~19为首次从丁香属植物中分离得到,化合物4、6、12为首次从紫丁香叶中分离得到。Objective To determine the chemical constituents of Syringa oblata (S.oblata) leaves.Methods The chemical components of S.oblata leaves were separated and purified by column chromatography with silica gel,ODS,and preparative HPLC.The structures of the chemical components were determined comprehensively with nuclear magnetic resonance and mass spectrum.Results Totally 19 compounds were isolated ftom S.oblata leaves and identified as syringalactone B (1),(8E)-ligstroside (2),(8E)-ligustroside (3),hydroxyframoside (4),fraxiformoside (5),oleoacteoside (6),syringopicroside (7),tetracentronside B (8),(+) pinoresinol-4-O-β-D-glucopyranoside (9),4,4'-dimethoxy-3'-hydroxy-7,9':7',9-diepoxylignan-3-O-β-D-glucopyranoside (10),lariciresinol-4'-O-β-D-glucopyranoside (11),olivil-4'-O-β-D-glucopyranoside (12),isolariciresinol-4-O-β-D-glucopyranoside (13),syringin (14),coniferin (15),(4ξ)-α-terpineol 8-O-[α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside](16),(Z)-3-hexenyl β-D-glucopyranoside (17),benzyl alcohol-β-vicianoside (18),and gaultherin (19).Conclusion Compounds 5,10,15 and 16~19 have been first isolated from Syringa,and compounds 4,6,12 have been isolated for the first time from S.oblata leaves.

关 键 词：紫丁香叶 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学] R283[医药卫生—中医学]