脑衰反应调节蛋白在视神经损伤中的作用  

Role of collapsin response mediator proteins in optic nerve injury

作　　者：朱裕椿 席鑫源 杨珍 冯东福 ZHU Yuchun;XI Xinyuan;YANG Zhen;FENG Dongfu(Department of Neurosurgery,Shanghai Jiaotong University Affiliated Sixth People′s Hospital South Campus,Shanghai 201499;Institute of Trauma Medicine,Shanghai Jiaotong University School of Medicine,Shanghai 201999,China)

机构地区：[1]上海交通大学附属第六人民医院南院神经外科,上海201499 [2]上海交通大学医学院创伤医学研究所,上海201999

出　　处：《基础医学与临床》2025年第1期102-106,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(82271388);上海市自然科学基金(22ZR1452700)。

摘　　要：脑衰反应调节蛋白(CRMPs),也被称为二氢嘧啶酶样蛋白,包含5个家族成员(CRMP1、CRMP2、CRMP3、CRMP4、CRMP5)。在中枢神经系统中,CRMPs主要参与神经元的分化迁移、突触可塑性和神经突的生长发育、导向延伸等多种生理过程。近期研究发现视神经损伤后,通过抑制或降低CRMPs的磷酸化可以影响视网膜神经节细胞(RGCs)的存活及其轴突再生,这可能会为未来视神经损伤治疗提供新的思路。Collapsin response mediator proteins(CRMPs),also known as dihydropyrimidine-like proteins,contain five isoforms(CRMP1,CRMP2,CRMP3,CRMP4,CRMP5).In central nervous system,CRMPs are mainly involved in a variety of physiological processes such as neuronal differentiation and migration,synaptic plasticity,neurite growth and development and guiding extension.Recent studies have found that inhibiting or reducing the phosphorylation of CRMPs can affect the survival and axonal regeneration of retinal ganglion cells(RGCs)after optic nerve injury,which may provide new ideas for the treatment of optic nerve injury in the future.

关 键 词：脑衰反应调节蛋白 视神经损伤 视网膜神经节细胞 轴突再生 

分 类 号：R34[医药卫生—基础医学]