新生儿急性肺损伤的发病机制  

Pathogenesis of acute lung injury of the newborns

作　　者：杨若彤 赵国英[1] 王浩[1] YANG Ruotong;ZHAO Guoying;WANG Hao(Department of Pediatrics,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院儿科,山东滨州256600

出　　处：《基础医学与临床》2025年第1期135-139,共5页Basic and Clinical Medicine

摘　　要：新生儿由于气道较窄、肺泡发育不完全等因素易发生新生儿急性肺损伤(ALI),严重者可发展为新生儿急性呼吸窘迫综合征(ARDS)。导致新生儿ALI发生及进展的机制涉及各个方面,主要包括氧化应激、铁死亡、炎性反应和肺表面活性物质的减少。期待相关机制的进一步研究可以为探索新型治疗方案提供方向。Due to factors such as narrow airways and incomplete development of alveoli,newborns are prone to acute lung injury(ALI),which may progress to severe condition known as acute respiratory distress syndrome(ARDS).The mechanisms underlying the occurrence and progression of ALI in newborns involve various aspects,including oxidative stress,iron death,inflammatory response and reduction of pulmonary surfactant.Further research into these mechanisms is expected to provide strategy to guide clinical management in novo pathway.

关 键 词：新生儿 急性肺损伤 急性呼吸窘迫综合征 发病机制 

分 类 号：R722.1[医药卫生—儿科]