消化系统恶性肿瘤患者围手术期输注不同储存时间红细胞的效果分析  

Effect analysis of different storage time red blood cell infusion during perioperative period in patients with malignant tumors of digestive system

作　　者：刘桂芳[1] 金勇[1] 袁圆 韩霜[1] LIU Gui-fang;JIN Yong;YUAN Yuan(Dongtai People's Hospital blood transfusion Department,Jiangsu Dongtai 224200)

机构地区：[1]东台市人民医院输血科,江苏东台224200

出　　处：《医学检验与临床》2024年第11期17-20,共4页Medical Laboratory Science and Clinics

基　　金：盐城市科技计划项目,项目名称:胃瘤外泌体中的circPVT1介导miR-497-5p/VEGFA轴促进血管生成的机制研究,项目编号:YK2021084。

摘　　要：目的:探讨围手术期消化系统恶性肿瘤患者在输注不同储存时间地去白细胞悬浮红细胞后的效果和影响。方法:收集2020年6月-2023年6月期间东台市人民医院收治的110例已经确诊为消化系统恶性肿瘤患者的临床资料,均在围手术期进行了输注去白细胞悬浮红细胞的治疗,将输注储存时间≥14天去白细胞悬浮红细胞的患者纳入观察组(n=60),将输注储存时间<14天去白细胞悬浮红细胞的患者纳入对照组(n=50)。比较两组研究对象输血前后血常规、肝功能、电解质、凝血功能的变化。结果:观察组输血有效率为88.3%(53/60),对照组输血有效率为86.0%(43/50),两组研究对象在输血有效率的比较上无差异(P>0.05)。输血后两组研究对象的Hb、HCT相比较输血前均明显升高,差异具有统计学意义(P<0.05),而PLT则无明显变化(P>0.05);输血后观察组与对照组的Hb、PLT、HCT比较无差异(P>0.05)。输血后两组研究对象的K^(+)、T-Bil、D-Bil相比较输血前均明显升高,Ca^(2+)明显下降,差异具有统计学意义(P<0.05);输血后观察组K^(+)、T-Bil明显高于对照组,差异具有统计学意义(P<0.05)。输血前后观察组、对照组PT没有明显变化,比较无差异(P>0.05),APTT上升,差异具有统计学意义(P<0.05);输血后观察组与对照组PT、APTT比较无差异(P>0.05)。结论:围手术期消化系统恶性肿瘤患者输注≥14天地去白细胞悬浮红细胞后地对患者血常规、凝血功能的影响较小,对K^(+)、T-Bil有一定程度影响。Objective:To investigate the effect and influence of infusion of leucocyte suspended red cells for different storage time in patients with digestive system malignant tumors during perioperative period.Methods:Clinical data of 110 patients diagnosed with digestive system malignant tumors admitted to Dongtai People's Hospital from June 2020 to June 2023 were collected.All patients were treated with transfusion of leucocyte suspended red blood cells during perioperative period.Patients with infusion storage time of leucocyte suspended red blood cells≥14 days were included in the observation group(n=60).Patients whose infusion storage time was<14 days were included in the control group(n=50).The changes of blood routine,liver function,electrolyte and coagulation function before and after transfusion were compared between the two groups.Results:The blood transfusion effective rate of the observation group was 88.3%(53/60),while that of the control group was 86.0%(43/50).In comparison,there was no significant difference between the blood transfusion effective rate of the control group and the observation group(P>0.05).After blood transfusion,Hb and HCT of the two groups were significantly increased compared with those before blood transfusion,with statistical significance(P<0.05),while PLT had no significant change(P>0.05).There were no differences in Hb,PLT and HCT between the observation group and the control group after blood transfusion(P>0.05).After blood transfusion,K^(+),T-Bil and D-Bil in both observation group and control group were significantly increased compared with those before blood transfusion,while Ca^(2+)was significantly decreased,with statistical significance(P<0.05).After blood transfusion,the K^(+)and T-Bil of the observation group were significantly higher than those of the control group,and their differences were statistically significant(P<0.05).There was no significant difference in PT between the observation group and the control group before and after blood transfusion(P>0.05).Conclusion:I

关 键 词：消化系统恶性肿瘤 围手术期 储存时间 去白细胞红细胞 

分 类 号：R73[医药卫生—肿瘤]