血清VEGF、ET-1表达与子痫前期患者病情严重程度的关系  

The Relationship Between Serum VEGF and ET-1 Expression and the Severity of Preeclampsia in Patients

作　　者：胡茜琪 操银环 陆国平 HU Xiqi;CAO Yinhuan;LU Guoping(Department of Biology and Health,Chizhou Vocational and Technical College,Chizhou 247000 China;Department of Laboratory Medicine,Fuyang Hospital of Anhui Medical University,Fuyang 236000 China)

机构地区：[1]池州职业技术学院生物与健康系,安徽池州247000 [2]安徽医科大学附属阜阳医院检验科,安徽阜阳236000

出　　处：《锦州医科大学学报》2024年第6期75-79,共5页Journal of Jinzhou Medical University

基　　金：2022年度安徽省高等学校科学研究项目,项目编号:2022AH052859;2021年度阜阳市卫生健康委科研项目,项目编号:FY2021-130。

摘　　要：目的分析血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、内皮素-1(endothelin-1,ET-1)表达与子痫前期患者病情严重程度的关系。方法前瞻性研究纳入2022年1月至2024年1月安徽医科大学附属阜阳医院诊疗的60例子痫前期患者作为研究对象。患者均接受子痫前期常规干预与规律性产检,将规律产检期间发展至重度子痫前期的患者纳入重度组,其他病情未进展的患者纳入轻度组;比较重度组与轻度组患者基线资料与确诊时血清VEGF、ET-1表达,重点分析血清VEGF、ET-1表达与子痫前期患者病情严重程度之间的关系。结果60例子痫前期患者规律性产检与干预期间,疾病发展至重度者8例,占比13.33%(8/60)。重度组与轻度组患者年龄、确诊时体质量指数(body mass index,BMI)、产妇类型、确诊孕周等基线资料比较,差异无统计学意义(P>0.05);重度组确诊时血压高于轻度组,血清VEGF、ET-1表达高于轻度组,差异有统计学意义(P<0.05)。轻度子痫前期患者发展至重度风险可能与确诊时血清VEGF、ET-1水平有关,与二者均分别呈正向剂量反应关系(非线性检验P<0.05),当子痫前期患者确诊时血清VEGF>6.48 pg/mL、ET-1>48.24 ng/L时,其发展为重度的风险随血清VEGF、ET-1升高而增加。交互作用发现,子痫前期患者确诊时血清VEGF、ET-1表达对病情严重程度存在正向交互作用,即子痫前期患者确诊时血清VEGF、ET-1同时高表达时(VEGF>5.80 pg/mL、ET-1>47.26 ng/L),患者病情持续进展至重度的风险是血清VEGF、ET-1同时低表达时(VEGF≤5.80 pg/mL、ET-1≤47.26 ng/L)的8.89倍。结论子痫前期患者病情严重程度可能与确诊时血清VEGF、ET-1表达有关,随着血清VEGF、ET-1表达升高,患者病情进展风险增加,且二者对病情严重程度的影响为交互影响。Objective To analyze the relationship between the expression of serum vascular endothelial growth factor(VEGF)and endothelin-1(ET-1)and the severity of preeclampsia in patients.Methods A prospective study was conducted,including 60 patients with preeclampsia who were diagnosed and treated in Fuyang Hospital of Anhui Medical University from January 2022 to January 2024 as the study subjects.All patients received routine intervention and regular prenatal checkups for preeclampsia.Patients who progressed to severe preeclampsia during regular prenatal checkups were included in the severe group,while patients who did not progress to other conditions were included in the mild group.The baseline data and serum VEGF and ET-1 expression at diagnosis were compared between the severe group and the mild group,and the relationship between serum VEGF and ET-1 expression and the severity of preeclampsia was analyzed.Results During regular prenatal examinations and interventions,8 out of 60 patients with preeclampsia experienced severe disease progression,accounting for 13.33%(8/60).There was no difference in baseline data such as age,body mass index(BMI)at diagnosis,maternal type,and gestational age between the severe and mild groups of patients(P>0.05).When diagnosed,the blood pressure in the severe group was higher than that in the mild group,and the expression of serum VEGF and ET-1 was higher than that in the mild group,with statistical significant differences(P<0.05).The development of mild preeclampsia to severe risk may be related to the serum VEGF and ET-1 levels at the time of diagnosis,and there was a positive dose-response relationship between the two(non-linear test P<0.05).When serum VEGF>6.48 pg/mL and ET-1>48.24 ng/L were diagnosed in preeclampsia patients,the risk of developing to severe risk increased with the increase of serum VEGF and ET-1.The interaction found that the expression of serum VEGF and ET-1 in patients with preeclampsia had a positive interaction with the severity of the disease,that is,when the

关 键 词：子痫前期 病情程度 血清血管内皮生长因子 血清内皮素-1 

分 类 号：R714[医药卫生—妇产科学]