伊伐布雷定用于心房颤动心室率控制的研究进展  

Ivabradine for Heart Rate Control in Atrial Fibrillation

作　　者：王竸婧 姚建晗 黄新苗 郭志福 曹江 WANG Jingjing;YAO Jianhan;HUANG Xinmiao;GUO Zhifu;CAO Jiang(Department of Cardiovasology,The First Affiliated Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院心血管内科,上海200433

出　　处：《心血管病学进展》2024年第12期1066-1069,共4页Advances in Cardiovascular Diseases

基　　金：上海市申康医院发展中心《促进市级医院临床技能与临床创新能力三年行动计划》项目(SHDC2020CR1040B-4)。

摘　　要：控制心室率是心房颤动(AF)治疗的重要方面。目前可用于AF心室率控制的药物受到副作用和疗效的限制。伊伐布雷定通过抑制窦房结funny电流(I_(f)),降低窦性心室率。有研究表明,房室结中也存在I_(f)通道,阻断房室结I_(f)会减慢房室传导,可降低AF的心室率。近期伊伐布雷定用于控制AF心室率治疗引起较多关注。现就伊伐布雷定在AF心室率控制方面的基础和临床研究做一综述。Control of ventricular rate is recommended for patients with atrial fibrillation(AF).Currently available agents for rate control in AF are limited by adverse effects and their ability to attain target heart rate.By inhibiting funny current(I_(f))of the sinoatrial node,ivabradine reduces sinus heart rate.However,it has been shown that I_(f) channels can also be found in atrioventricular node and blocking atrioventricular nodal I_(f) slows atrioventricular conduction,resulting in lower ventricular rates during AF.Ivabradine has drawn recent interest as a rate control agent for AF.In this review,we focus on the basic and clinical evidence for ventricular rate control of ivabradine in AF.

关 键 词：心房颤动 funny电流 伊伐布雷定 心室率控制 房室结 

分 类 号：R541.75[医药卫生—心血管疾病]