人附睾蛋白4在心肾疾病中的研究进展  

Human Epididymis Protein 4 in Cardiovascular and Renal Diseases

作　　者：刘志斌 唐毅[1,2] 胡政琪 刘天承 彭建强 何晋[1,2] LIU Zhibin;TANG Yi;HU Zhengqi;LIU Tiancheng;PENG Jianqiang;HE Jin(Department of Cardiology,Hunan Provincial People’s Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 410005,Hunan,China;Clinical Medicine Research Center of Heart Failure of Hunan Province,Changsha 410005,Hunan,China)

机构地区：[1]湖南师范大学附属第一医院湖南省人民医院心血管内科,湖南长沙410005 [2]湖南省心力衰竭临床医学研究中心,湖南长沙410005

出　　处：《心血管病学进展》2024年第12期1110-1113,共4页Advances in Cardiovascular Diseases

基　　金：湖南省卫生健康委员科研计划项目(202103012371);仁术基金重点培育项目(RS2022A12);湖南省科技创新重点工程(2020SK1013)。

摘　　要：人附睾蛋白4(HE4)为具有2个乳清酸性蛋白四二硫化物核心结构域、124个氨基酸的多肽,是一种乳清酸性蛋白,属于蛋白酶抑制剂家族中的一种。HE4目前广泛应用于妇科相关疾病的诊断及预后评估,近年来研究显示HE4在心血管及肾脏疾病患者中呈现较高水平表达,尤其是在心力衰竭、急性冠脉综合征和心肌病等心血管疾病及慢性肾脏病等肾脏疾病中扮演着重要角色。现对HE4在心血管及肾脏疾病中的研究现状做一综述。Human epididymis protein 4(HE4)is a peptide with 2 whey acidic protein four-disculfidecore domains,consisting of 124 amino acids.It is a whey acidic protein and belongs to the family of protease inhibitors.HE4 is currently widely used in the diagnosis and prognosis assessment of gynecological diseases.In recent years,studies have shown that HE4 exhibits high levels of expression in patients with cardiovascular and renal diseases,especially playing an important role in cardiovascular diseases such as heart failure,acute coronary syndrome,cardiomyopathy,as well as chronic kidney disease.This article provides an overview of the current research status of HE4 in cardiovascular and renal diseases.

关 键 词：人附睾蛋白4 心力衰竭 急性冠脉综合征 心肌病 慢性肾脏病 

分 类 号：R692[医药卫生—泌尿科学] R54[医药卫生—外科学]