p300/CBP调控心脏衰老及其相关疾病的机制  

Mechanisms of p300/CBP in Regulating Cardiac Aging and Associated Diseases

作　　者：贺文超 张正义[1] HE Wenchao;ZHANG Zhengyi(The Second Hospital&Clinical Medical School,Lanzhou University,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第二医院第二临床医学院,甘肃兰州730000

出　　处：《心血管病学进展》2024年第12期1118-1122,共5页Advances in Cardiovascular Diseases

基　　金：甘肃省社会发展领域重点研发计划(23YFFFA0039)。

摘　　要：随着人口老龄化的不断发展,心脏衰老导致心脏肥大、心肌纤维化增加、电信号传导异常等病理变化所引起的心血管疾病发病率逐年升高。以p300/CBP为主的组蛋白乙酰转移酶介导的表观遗传调控在其发病过程起重要作用。现总结目前关于p300/CBP的结构、功能、调控心血管疾病发展的作用机制及其靶向药物的研究现状,并对其未来的应用和发展前景进行展望,为治疗心脏衰老相关的疾病提供新的思路。With the continuous development of the aging population,the incidence of cardiovascular diseases caused by pathological changes such as cardiac hypertrophy,increased myocardial fibrosis,and abnormal electrical signal conduction due to cardiac aging is rising year by year.Histone acetyltransferases,especially p300/CBP,play a significant role in the pathogenesis of these diseases through epigenetic regulation.This summary reviews the current research on the structure,function,mechanisms of action in the development of cardiovascular diseases,and the current status of research on targeted drugs for p300/CBP.It also provides an outlook on future applications and prospects,offering new perspectives for the treatment of cardiac age related diseases.

关 键 词：组蛋白乙酰转移酶 P300/CBP 心脏衰老 心房颤动 

分 类 号：R541[医药卫生—心血管疾病]