2型糖尿病持续时间与女性生殖系统恶性肿瘤关系的流行病学研究进展  

Progress in Epidemiological Research on Relationship Between Duration of Type 2 Diabetes and Risk of Malignant Tumors of Female Reproductive System

作　　者：周晓慧 李卓颖 刘湾湾 陆佩文 沈秋明 徐群[4] 项永兵[2,3] ZHOU Xiaohui;LI Zhuoying;LIU Wanwan;LU Peiwen;SHEN Qiuming;XU Qun;XIANG Yongbing(School of Public Health,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Department of Epidemiology,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200032,China;State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China;Health Management Center,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学公共卫生学院,上海200025 [2]上海市肿瘤研究所流行病学研究室,上海200032 [3]上海交通大学医学院附属仁济医院肿瘤系统医学全国重点实验室,上海200127 [4]上海交通大学医学院附属仁济医院健康管理中心,上海200127

出　　处：《肿瘤防治研究》2024年第12期977-988,共12页Cancer Research on Prevention and Treatment

基　　金：国家重点研发计划(2021YFC2500404,2021YFC2500405)。

摘　　要：2型糖尿病(T2DM)持续时间与女性生殖系统恶性肿瘤的关系复杂多样。一些大型人群队列研究表明,T2DM持续时间与乳腺癌、子宫内膜癌的发生呈负相关。此外,也有大量研究表明T2DM诊断短期内出现乳腺癌和子宫内膜癌风险最高,并且在糖尿病持续时间较长的患者中,风险仍然显著高于非糖尿病人群;这提示因果倒置偏倚和潜在检测偏倚可能发挥了一定的作用,但T2DM仍是乳腺癌和子宫内膜癌发生的重要危险因素。糖尿病与宫颈癌和卵巢癌发生关联的研究较少,且不同地区结果不一致。未来的流行病学研究应集中在更大规模和更长随访期的前瞻性研究,以进一步探究糖尿病与宫颈癌和卵巢癌之间的关系,并深入解析糖尿病和女性生殖系统癌症之间的生物学机制,从而为有效的癌症预防和早期干预策略提供理论支持。The relationship between the duration of type 2 diabetes mellitus(T2DM)and the risk of female reproductive malignancies is complex and multifaceted.Large population cohort studies revealed a negative association between the duration of T2DM and the incidence of breast cancer and endometrial cancer.Furthermore,the risk of breast and endometrial cancer is the highest within a short time after T2DM diagnosis and remains remarkably higher in patients with longer diabetes duration than in the nondiabetic population.This phenomenon suggests causal reverse bias and potential detection bias.Nevertheless,T2DM remains an important risk factor for breast and endometrial cancer.Research on the association between diabetes with cervical and ovarian cancer is limited,and results vary by region.Future epidemiological studies should focus on large prospective studies with long follow-up to further investigate this association.Research into the biological mechanisms linking diabetes and female reproductive cancers is also necessary to develop effective cancer prevention and early intervention strategies.

关 键 词：2型糖尿病 女性生殖系统癌症 潜在检测偏倚 持续时间 流行病学 

分 类 号：R587.1[医药卫生—内分泌] R737.3[医药卫生—内科学]