皮炎灵搽剂治疗慢性湿疹的临床疗效和安全性评价  

Efficacy and Safety of Piyanling Liniment in the Treatment of Chronic Eczema

作　　者：王晓梅 刘小平 杨芷怡 杨洁 张薛 沈麟松 高媛 尚双双 张琦 朱斌 杨阳 WANG Xiao-mei;LIU Xiao-ping;YANG Zhi-yi;YANG Jie;ZHANG Xue;SHEN Lin-song;GAO Yuan;SHANG Shuang-shuang;ZHANG Qi;ZHU Bin;YANG Yang(The Affiliated Huaihai Hospital of Xuzhou Medical University/the 71st Group Army Hospital of CPLA Army,Xuzhou 221004,China)

机构地区：[1]徐州医科大学附属淮海医院/陆军第71集团军医院,江苏徐州221004

出　　处：《解放军药学学报》2024年第6期532-536,共5页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：陆军科技英才培养工程资助项目,No.ZG2019-174;陆军第71集团军医院院内科研课题经费资助项目,No.YNMS-2021009。

摘　　要：目的研究皮炎灵搽剂治疗慢性湿疹的临床疗效和安全性。方法选取某医院门诊皮肤科慢性湿疹患者98例,随机分为2组。其中,皮炎灵搽剂组49例患者使用皮炎灵搽剂进行治疗;哈西奈德溶液组49例患者使用哈西奈德溶液进行治疗;均为每日2次,每次用量0.5ml·cm^(-2)。观察治疗前及治疗4、7、10、14d后两组患者患处皮损面积、皮损程度、瘙痒程度及色素沉着程度等临床症状变化情况,判定临床疗效,并比较药物不良反应发生情况。结果两组患者随着治疗时间的增加,其皮损面积、皮损程度、瘙痒程度、色素沉着程度均逐渐好转;皮炎灵搽剂对慢性湿疹皮损面积减少、色素沉着改善的疗效等同于哈西奈德溶液,对慢性湿疹皮损、瘙痒改善的疗效优于哈西奈德溶液。经过2个疗程的治疗后,皮炎灵搽剂组患者、哈西奈德溶液组患者的治疗总有效率分别为91.84%、81.63%,皮炎灵搽剂治疗慢性湿疹的临床疗效优于哈西奈德溶液(P=0.001)。两组患者均未发生药物不良反应。结论皮炎灵搽剂用于临床治疗慢性湿疹安全有效。Objective To investigate the clinical efficacy and safety of Piyanling liniment in the treatment of chronic eczema.Methods A total of 98 patients with chronic eczema were randomly divided into two groups.The Piyanling liniment group(n=49)was treated with Piyanling liniment while the Halcinonide solution group(n=49)was given Halcinonide solution.Both groups applied the respective treatment twice daily,at a dosage of 0.5 ml·cm^(-2) each time.Clinical symptoms,including the skin lesion size,skin lesion degree,pruritus degree,and pigmentation degree,were assessed before treatment and after 4,7,10,and 14 days of treatment.Additionally,the clinical efficacy and incidence of adverse drug reactions were compared between the two groups.Results Both groups exhibited progressive improvements in the skin lesion size,skin lesion degree,pruritus degree,and pigmentation degree as the duration of treatment increased.Piyanling liniment demonstrated comparable efficacy to Halcinonide solution in reducing skin lesion areas and improving pigmentation in chronic eczema.Furthermore,Piyanling liniment showed superior efficacy in enhancing skin lesions and alleviating pruritus compared to Halcinonide solution.After two courses of treatment,the total effective rates for the Piyanling liniment group and Halcinonide solution group were 91.84%and 81.63%,respectively.The clinical efficacy of Piyanling liniment in the treatment of chronic eczema was superior to that of Halcinonide solution(P=0.001).No adverse drug reactions were reported in either group.Conclusion Piyanling liniment is a safe and effective treatment for chronic eczema.

关 键 词：慢性湿疹 皮炎灵搽剂 哈西奈德溶液 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]