一种促进消化功能的复合醋口服液动物实验研究  

A Compound Vinegar Oral Solution for Promoting Digestion:an Animal Experimental Study

作　　者：张露勇[1] 马利波 郑济凡 朵慧 刘师卜[1] 刘婷[1] ZHANG Lu-yong;MA Li-bo;ZHENG Ji-fan;DUO Hui;LIU Shi-bo;LIU Ting(National Institutes for Food and Drug Control,Beijing 102629,China)

机构地区：[1]中国食品药品检定研究院,北京102629

出　　处：《解放军药学学报》2024年第6期541-545,共5页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的研究复配健味醋口服液的促进消化功能。方法SPF级SD种雄性大鼠36只,随机分为4个剂量组,实验组高、中、低(10.00、3.33、1.67ml·kg^(-1))剂量经口给予试药,溶剂对照组经口给予蒸馏水,开展胃液分泌量和胃蛋白酶活性实验;KM种雄性小鼠50只,随机分为5个剂量组,实验组高、中、低(10.00、3.33、1.67ml·kg^(-1))剂量经口给予开展小肠运动实验,设置溶剂对照组和模型对照组给予等体积的蒸馏水。结果用SD种大鼠和KM种小鼠连续灌胃给予健味醋口服液31d和15d,大鼠各周体质量、体质量增加值、摄食量和食物利用率未见显著变化。健味醋口服液高剂量组对胃液总量、胃液排出量、胃蛋白酶活性和胃蛋白酶排出量显著增加,对小鼠小肠蠕动缓慢模型具有明显推进作用;中剂量组对胃蛋白酶活性和胃蛋白酶排出量显著增加;低剂量组对胃蛋白酶活性显著增加。结论该健味醋口服液具有消化功能促进作用。Objective To study the digestion promoting function of a compound Jianweicu oral solution(JW)in mice and rats.Methods 36 SD male rats were randomly divided into 4 dose groups.Rats in the high,medium,low dose groups and solvent control group were orally administered with 10.00,3.33,1.67 ml·kg^(-1) JW,and distilled water respectively,whose gastric fluid secretion and pepsin were assayed.50 KM male mice were randomly divided into 5 dose groups.Mice in the high,medium,low dose groups,solvent control,model control groups were orally administered with 10.00,3.33,1.67 ml·kg^(-1) JW,and distilled water respectively before small bowel motility tests were carried out.Results No significant changes in body weight,body weight gain,food intake or food utilization were observed in rats during the 31 days of gavage administration and in mice during the 15 days of gavage administration in any of the weeks.10.00 ml·kg^(-1) JW significantly increased the total amount of gastric juice,gastric juice discharge,pepsin activity and pepsin discharge in rats,and intestinal motility in mice.3.33 ml·kg^(-1) JW increased pepsin activity and pepsin excretion,1.67 ml·kg^(-1) JW increased pepsin activity in rats.Conclusion The compounded JW can help promote digestion.

关 键 词：消化功能 动物实验 健胃醋口服液 胃蛋白酶 小肠蠕动 

分 类 号：R917[医药卫生—药物分析学]