全息血管硬度分析技术评价不同病程1型糖尿病患儿颈动脉弹性功能  

Evaluation of Carotid Artery Elasticity in Children of Different Disease Courses with Type I Diabetes Mellitus via RF-Data Based Quantitative Analysis on Vessel Stiffness Technique

作　　者：纪淑姣[1] 徐雪艳 朱好辉 牛瑜琳 张喜君 陈永兴 JI Shujiao;XU Xueyan;ZHU Haohui;NIU Yulin;ZHANG Xijun;CHEN Yongxing(Department of Ultrasound,Henan Provincial People’s Hospital,ZhenZhou University People’s Hospital,Zhenzhou 450003,China;不详)

机构地区：[1]河南省胸科医院、郑州大学附属胸科医院超声科,河南郑州450000 [2]河南省人民医院、郑州大学人民医院超声科,河南郑州450003 [3]郑州大学附属儿童医院(河南省儿童医院)内分泌遗传代谢科,河南郑州450000

出　　处：《中国医学影像学杂志》2024年第12期1231-1236,共6页Chinese Journal of Medical Imaging

基　　金：河南省科技厅自然科学基金项目(222300420356)。

摘　　要：目的应用全息血管硬度分析技术评价1型糖尿病(T1DM)患儿颈动脉弹性功能与糖尿病病程和血糖控制情况的相关性。资料与方法前瞻性收集2019年9月—2021年11月河南省胸科医院儿科、河南省人民医院儿科、河南省儿童医院内分泌遗传代谢科已确诊的T1DM患儿75例,按照T1DM患儿病程分为长病程组(病程≥5年)30例,短病程组(病程<5年)45例;同时收集年龄、性别相匹配的正常对照组30例。用全息血管硬度分析技术测量颈总动脉血管收缩期直径、血管位移、脉搏波传导速度(PWV)和硬度系数、颈总动脉内-中膜厚度;同期收集血糖及血脂指标,比较3组间各参数的差异。结果长病程组、短病程组空腹血糖、糖化血红蛋白和内-中膜厚度均高于对照组,差异有统计学意义(P均<0.05);3组PWV、硬度系数、血管位移差异有统计学意义(F=22.854、16.811,H=33.214,P均<0.001)。病程与PWV、硬度系数具有相关性(r=0.621、0.517,P<0.001);糖化血红蛋白与PWV具有相关性(r=0.562,P<0.001)。结论T1DM患儿早期即可出现颈动脉弹性减退,高血糖持续时间越长,动脉弹性受损程度越重。全息血管硬度分析技术是一种简单有效且无创的动脉弹性评估方法,为临床提供诊疗依据。Purpose To evaluate the changes of carotid artery elasticity in children with type 1 diabetes mellitus(T1DM)via RF-data based quantitative analysis on vessel stiffness technique(R-VQS),and to detect its correlation with the duration of diabetes mellitus and blood sugar control.Materials and Methods A total of 75 children with T1DM from the Pediatrics Department of Henan Chest Hospital,the Pediatrics Department of Henan People's Hospital,and the Endocrinology,Genetics,and Metabolism Department of Henan Children's Hospital were prospectively collected from September 2019 to November 2021.According to the T1DM duration,all patients were divided into long course group(duration≥5 years,n=30 cases)and short course group(duration<5 years,n=45 cases).And 30 age and sex matched controls were also collected.The systolic diameter(Diam),vascular displacement(Dist),pulse wave velocity(PWV),stiffness coefficient(HC)and intima-media thickness(IMT)of common carotid artery were measured by R-VQS.Fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),triglyceride(TG),serum total cholesterol(TC),high-density lipoprotein(HDL),low-density lipoprotein cholesterol(LDL)were collected to compared the differences of parameters among the three groups.Results The FBG,HbA1c and IMT of the long and short course groups were all significantly higher than those of control group(all P<0.05).There were statistically significant differences in PWV and HC among the three groups(F=22.854,P<0.001;F=16.811,P<0.001;H=33.214,P<0.001).The course of disease was moderately correlated with PWV and HC(r=0.621,0.517,respectively,P<0.001).HbA1c was moderately correlated with PWV(r=0.562,P<0.001).Conclusion Early onset of T1DM in children may lead to decreased carotid artery elasticity,and prolonged hyperglycemia can aggravate the degree of arterial elasticity damage.R-VQS is a simple,effective,and non-invasive method for assessing arterial elasticity,providing a basis for clinical diagnosis and treatment.

关 键 词：全息血管硬度分析技术 颈动脉弹性 糖尿病 1型 儿童 

分 类 号：R587.1[医药卫生—内分泌] R445.1[医药卫生—内科学]