二维超声丘脑横切面评估大脑外侧裂发育  

Value of Two-Dimensional Transverse Section of Thalamus in Evaluating the Developmental Status of Lateral Fissure of Fetus

作　　者：祝忠强 王兴运 任苓 ZHU Zhongqiang;WANG Xingyun;REN Ling(Department of Ultrasound Medicine,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]赣南医科大学第一临床医学院,江西赣州341000 [2]赣南医科大学第一附属医院超声医学科,江西赣州341000

出　　处：《中国医学影像学杂志》2024年第12期1262-1265,1276,共5页Chinese Journal of Medical Imaging

摘　　要：目的 探讨应用二维超声丘脑水平横切面评估20~36+6周正常胎儿外侧裂发育状况的价值。资料与方法 前瞻性选取2023年3月1日—2024年3月1日赣南医科大学第一附属医院的正常单胎妊娠孕妇,应用二维超声对胎儿颅脑进行成像。运用二维丘脑水平横切面观察272例20~36+6周正常胎儿的外侧裂形态。在二维丘脑水平横切面测量外侧裂宽度和深度,并建立20~36+6周正常胎儿外侧裂宽度和深度的参考值范围。评估检验观察者内和观察者间测量外侧裂宽度和深度的可重复性。结果本研究成功入组272例20~36+6周正常胎儿,建立了20~36+6周正常胎儿的外侧裂宽度和深度的参考值范围。胎儿外侧裂宽度和深度随孕龄增长呈线性增长。外侧裂宽度(mm)=16.92+1.18孕龄,外侧裂深度(mm)=9.77+0.86孕龄。观察者内和观察者间的一致性较好(ICC均>0.850);各个Bland-Altman图中超过95%的点位于95%的一致性限度范围内。结论 二维丘脑水平横切面外侧宽度和深度的测量参数可用于定量评估中晚孕期外侧裂形态变化,是产前评估大脑皮质发育简便可行的辅助方法,可用于指导后续的随访、转诊、产前咨询等工作。Purpose To investigate the value of two-dimension thalamic horizontal transverse section in the assessment of normal fetal lateral fissure development at 20-36+6 weeks.Materials and Methods It was a prospective cross-sectional study,normal single pregnant women who were examined in the First Affiliated Hospital of Gannan Medical University from March 1,2023 to March 1,2024 were selected for fetal brain imaging via two-dimensional ultrasound imaging technology.The morphology of lateral fissure of 272 normal fetuses at 20-36+6 weeks were observed with two-dimensional transverse section of thalamus.Lateral cleft width and depth were measured at a two-dimensional thalamic horizontal cross-section and a reference range of normal fetal lateral cleft width and depth was established at 20-36+6 weeks.The repeatability of lateral crack width and depth measurements within and between observers were all verified.Results A total of 272 normal fetuses of 20-36+6 weeks were enrolled in the study.A range of reference values for lateral cleft width and depth of normal fetus at 20-36+6 weeks of normal gestation was established.The lateral fetal fissure width and depth increased linearly with gestational age.The lateral fetal fissure width(mm)=-16.92+1.18 gestational age,and the lateral fetal fissure depth(mm)=-9.77+0.86 gestational age,with good intra-and inter-observer agreement(intra-class correlation coefficient,ICC>0.850).More than 95%of the points in each Bland-Altman plot fall within the 95%consistency limit.Conclusion Two-dimensional thalamic horizontal transverse section can be used to observe the morphological changes of lateral fella in middle and late pregnancy.It is a simple and feasible method for prenatal assessment of cerebral cortex development,and can be used to guide follow-up,referral,prenatal consultation and other work.

关 键 词：超声检查 产前 胎儿发育 外侧裂 

分 类 号：R714.5[医药卫生—妇产科学] R445.1[医药卫生—临床医学]