植物源外泌体样纳米囊泡刺激成骨细胞、抑制破骨细胞并促进成骨  

Plant-derived exosome-like nanovesicles stimulate osteoblasts,inhibit osteoclasts,and promote osteogenesis

作　　者：药文鑫 王毅 蔡林[2] 冯晓波[1] Yao Wenxin;Wang Yi;Cai Lin;Feng Xiaobo(Department of Pain Management,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China;Department of Spine Surgery and Musculoskeletal Tumor,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei Province,China)

机构地区：[1]武汉大学中南医院疼痛科,湖北省武汉市430071 [2]武汉大学中南医院脊柱与骨肿瘤科,湖北省武汉市430071

出　　处：《中国组织工程研究》2025年第31期6765-6771,共7页Chinese Journal of Tissue Engineering Research

基　　金：武汉大学中南医院科技成果转化基金项目(LCYFMS2024002),项目负责人:冯晓波;武汉大学中南医院优博基金项目(ZNYB2023004),项目负责人:王毅。

摘　　要：背景:骨质疏松症易引发病理性骨折且严重影响患者的生活质量,植物源外泌体样纳米囊泡在调节骨质疏松症骨平衡方面发挥着重要作用。目的:综述不同植物源外泌体样纳米囊泡在骨质疏松症治疗中的研究现状与展望。方法:通过计算机在PubMed、Web of Science、中国知网中检索1995年1月至2024年3月发表的相关文献,以“osteoporosis,plant-derived exosome-like nanovesicles,exosomes,osteoblasts,osteoclasts”为英文检索词,以“骨质疏松症,植物源外泌体样纳米囊泡,外泌体,成骨细胞,破骨细胞”为中文检索词,最终纳入53篇文献进行分析。结果与结论:植物源外泌体样纳米囊泡具有生物相容性、低毒性和天然靶向性等优点,这些特性不仅确保了其在体内的稳定存在与有效作用,还避免了不必要的免疫反应,为长期治疗策略的设计奠定了基础。植物源外泌体样纳米囊泡可以通过刺激成骨细胞增殖、抑制破骨细胞分化以及促进成骨-抑制破骨双重作用抗骨质疏松症;此外,部分植物源外泌体样纳米囊泡因具有骨靶向性,未来或将成为新型示踪靶标和治疗方案广泛应用于骨质疏松症治疗过程中。BACKGROUND:Osteoporosis affects the quality of life of patients and is prone to pathological fractures,and plant-derived exosome-like nanovesicles play an important role in regulating bone balance in patients with osteoporosis.OBJECTIVE:To review the research status and prospect of different plant-derived exosome-like nanovesicles in the treatment of osteoporosis.METHODS:Relevant literature in PubMed,Web of Science,and CNKI databases were searched by computer.Search time was from January 1995 to March 2024.The Chinese and English search terms were“osteoporosis,plant-derived exosome-like nanovesicles,exosomes,osteoblasts,osteoclasts.”Finally,53 articles were included and analyzed.RESULTS AND CONCLUSION:Plant-derived exosom-like nanovesicles have the advantages of low biocompatibility,low toxicity,and natural targeting.These properties not only ensure its stable presence and effective effect in the body,but also avoid unnecessary immune responses,laying the foundation for the design of long-term treatment strategies.Plant-derived exosome-like nanovesicles can be anti-osteoporosis by stimulating osteoblast proliferation,inhibiting osteoclast differentiation,and promoting osteo-inhibition osteoclasts.In addition,some plant-derived exosome-like nanovesicles may be widely used in the diagnosis and treatment of osteoporosis in the future as novel tracer targets and treatment options due to their bone-targeting.

关 键 词：骨质疏松症 植物源性外泌体样纳米囊泡 外泌体 成骨细胞 破骨细胞 工程化外泌体 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R580