皮肤干细胞在银屑病中的研究进展  

Research progress of skin stem cells in psoriasis

作　　者：周芯竹 许静凯 夏青月 杨越 崔勇[2] Zhou Xinzhu;Xu Jingkai;Xia Qingyue;Yang Yue;Cui Yong(Department of Dermatology,Peking University China-Japan Friendship School of Clinical Medicine,Beijing 100029,China;Department of Dermatology,China-Japan Friendship Hospital,Beijing 100029,China;Peking Union Medical College and Chinese Academy Sciences,Beijing 100730,China;Clinical Research Institute of China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京大学中日友好临床医学院皮肤科,北京100029 [2]中日友好医院皮肤科,北京100029 [3]中国医学科学院北京协和医学院研究生院,北京100730 [4]中日友好临床医学研究所,北京100029

出　　处：《中国医学前沿杂志(电子版)》2024年第12期16-21,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金(82103100);中日友好医院“菁英计划”人才培育工程(ZRJY2023-QM27);中日友好医院高水平医院临床业务费专项研究(2024-NHLHCRF-TS-01

摘　　要：银屑病作为一种常见的慢性免疫系统介导的炎症性皮肤病,好发于任何年龄段。皮肤干细胞具有低免疫原性、抗炎及多向分化潜能等优势,因此受到了学者们的广泛关注,目前已开展了多项干细胞治疗银屑病的基础研究及临床试验。本文对皮肤中不同类型的干细胞在银屑病的发病及治疗中的研究进展进行综述,旨在推动干细胞在银屑病机制中的探索进程及干细胞疗法的进一步研究。Psoriasis,as a common chronic immune system-mediated inflammatory skin disease,occurs at any age.Skin stem cells have the advantages of low immunogenicity,anti-inflammatory and multidirectional differentiation potentials,and thus have received extensive attention from scholars,and several basic studies and clinical trials on stem cell therapy for psoriasis have been conducted.This article reviews the research progress of different types of stem cells in the skin in the pathogenesis and treatment of psoriasis,aiming to promote the exploration process of stem cells in the mechanism of psoriasis and further research on stem cell therapy.

关 键 词：银屑病 皮肤干细胞 干细胞疗法 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]