超声评估康柏西普联合视网膜激光光凝术治疗视网膜分支静脉阻塞合并黄斑水肿的疗效  

Efficacy of Conbercept combined with retinal laser photocoagulation in the treatment of branch retinal vein occlusion and macular edema by ultrasound evaluation

作　　者：兰图 谢利萍 罗成莉 李六燕 刘鹃 LAN Tu;XIE Liping;LUO Chengli;LI Liuyan;LIU Juan(Department of Ophthalmology,the First People’s Hospital of Zigong,Sichuan 643000,China)

机构地区：[1]四川省自贡市第一人民医院眼科,643000 [2]四川省自贡市第一人民医院手术室,643000 [3]四川省自贡市第一人民医院超声科,643000

出　　处：《临床超声医学杂志》2024年第12期1016-1020,共5页Journal of Clinical Ultrasound in Medicine

基　　金：四川省2020年度“杏林学者”学科人才科研提升计划(YYZX2020116)。

摘　　要：目的应用超声评估经玻璃体腔注射康柏西普联合视网膜激光光凝术治疗视网膜分支静脉阻塞(BRVO)合并黄斑水肿(ME)患者的疗效,探讨其临床价值。方法选取我院收治的BRVO合并ME患者62例,根据随机数表法分为光凝组和康柏西普组,每组各31例,其中光凝组行视网膜激光光凝术,康柏西普组在视网膜激光光凝术基础上行经玻璃体腔注射康柏西普治疗。分别于治疗前和治疗后8周进行超声检查,比较两组视网膜中央动脉(CRA)和眼动脉(OA)超声参数[收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)]的差异。获取两组治疗前后最佳矫正视力(BCVA)和黄斑中心凹视网膜厚度(CMT),比较BCVA、CMT、临床治疗有效率及不良反应发生率的差异。采用Pearson相关分析法分析BRVO合并ME患者CRA、OA超声参数与BCVA、CMT的相关性。结果治疗后,康柏西普组CRA的PSV、EDV、RI及BCVA均高于光凝组,CMT低于光凝组,差异均有统计学意义(均P<0.05)。康柏西普组临床治疗有效率为96.77%,高于光凝组(80.65%),差异有统计学意义(P<0.05)。治疗后,康柏西普组不良反应发生率为16.13%,与光凝组(29.03%)比较差异无统计学意义。Pearson相关性分析显示,BRVO合并ME患者CRA的PSV、EDV、RI与BCVA均呈正相关,CRA的PSV、EDV、RI与CMT均呈负相关(均P<0.05)。结论经玻璃体腔注射康柏西普联合视网膜激光光凝术治疗BRVO合并ME患者临床疗效显著,超声能准确评估其治疗效果,具有较好的临床价值。Objective To evaluate the efficacy of intravitreal injection of Conbercept combined with retinal laser photocoagulation in the treatment of patients with branch retinal vein occlusion(BRVO)and macular edema(ME)by ultrasound,and to explore its clinical value.Methods A total of 62 patients with BRVO and ME in our hospital were enrolle.According to random number table method,they were divided into photocoagulation group(31 cases,retinal laser photocoagulation)and Conbercept group(31 cases,intravitreal injection of Conbercept on the basis of retinal laser photocoagulation).All patients underwent ultrasound examination before and 8 weeks after treatment,then the ultrasound parameters[peak systolic velocity(PSV),end-diastolic velocity(EDV),resistance index(RI)]of central retinal artery(CRA)and ocular artery(OA),clinical curative effect,adverse reactions,best corrected visual acuity(BCVA)and central macular thickness(CMT)were compared between the two groups.The correlation between ultrasound parameters of CRA,OA and BCVA,CMT were analyzed by Pearson correlation analysis.Results Compared with the results in photocoagulation group after treatment,the BCVA,PSV,EDV and RI of CRA in Conbercept group were increased,while the CMT was decreased(all P<0.05).The curative effect in Conbercept group was higher than that in photocoagulation group(96.77%vs.80.65%,P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions between Conbercept group and photocoagulation group(16.13%vs.29.03%).Pearson correlation analysis showed that the PSV,EDV,RI of CRA were positively correlated with BCVA,while negatively correlated with CMT(all P<0.05).Conclusion Intravitreal injection of Conbercept combined with retinal laser photocoagulation has significant clinical curative effect in patients with BRVOand ME.Ultrasound can accurately assess the efficacy and has a certain clinical value.

关 键 词：超声检查 视网膜分支静脉阻塞 黄斑水肿 康柏西普 激光光凝术 疗效 

分 类 号：R445.1[医药卫生—影像医学与核医学]