微流控技术可控制备异形微纤维的研究进展  

Research progress on controllable fabrication of anisotropic microfibers by microfluidics

作　　者：巨晓洁[1] 何明炜 夏有强 汪伟[1] 褚良银[1] JU Xiaojie;HE Mingwei;XIA Youqiang;WANG Wei;CHU Liangyin(School of Chemical Engineering,Sichuan University,Chengdu 610065,Sichuan,China)

机构地区：[1]四川大学化学工程学院,四川成都610065

出　　处：《化工学报》2024年第11期3923-3934,共12页CIESC Journal

基　　金：国家自然科学基金项目(21991101);四川大学-中国核动力研究设计院联合创新基金项目(JG2022300)。

摘　　要：异形微纤维因其多样化的结构和功能被广泛应用于仿生材料、药物控释和生物医学等诸多领域。微流控技术作为一种新型的微纳材料制备技术,通过调节通道结构、流体物性和流动条件,可以实现多种异形微纤维的可控制备。综述了近年基于微流控技术制备面向医药、化工和环境等重要领域的异形微纤维的研究进展。介绍了通过设计微流控装置的通道结构实现可控制备实心、中空、纺锤状和螺旋状等异形微纤维的诸多策略,探讨了基于异形微纤维的微观结构实现其功能多样化的重要思路,展望了微流控技术在可控构建新型异形微纤维方面的发展趋势,以期通过加强流动机制和成型机理的研究为制备高仿生性的异形微纤维提供重要参考。Anisotropic microfibers have been widely used in many fields such as biomimetic materials,drugcontrolled release and biomedicine due to their diverse structures and functions.Microfluidic technology,as a new type of micro-nano material preparation technology,can achieve controllable preparation of various shaped microfibers by adjusting channel structure,fluid properties and flow conditions.This review summarizes recent progress on the controllable fabrication of diverse functional anisotropic microfibers by microfluidics,for use in fields such as pharmaceuticals,chemical engineering,and environment.Fabrication strategies for the controllable fabrication of anisotropic microfibers,including solid-shaped,hollow-shaped,spindle-shaped and spiral-shaped microfibers by designing the structure of microfluidics are introduced.Important ideas for diversifying the functions of shaped microfibers based on their microstructure are discussed.The future development of microfluidics for the controllable fabrication of novel anisotropic microfibers is prospected,with a view to providing important references for the fabrication of highly bionic anisotropic microfibers by strengthening the study of flow mechanism and molding mechanism.

关 键 词：微流控技术 异形微纤维 可控制备 功能化 

分 类 号：TQ469[化学工程—制药化工] TB34[一般工业技术—材料科学与工程]