血栓抽吸导管联合不同剂量替罗非班在急性心肌梗死急诊介入治疗中的应用效果  

Effect of Thrombus Aspiration Catheter Combined with Different Doses of Tirofiban in Emergency Interventional Treatment of Acute Myocardial Infarction

作　　者：黄锦华[1] 瞿珍清 Huang Jinhua;Qu Zhenqing(Department of Emergency,Foshan Gaoming District People's Hospital,Foshan 528500,Guangdong Province,China;Department of Cardiology,Foshan Gaoming District People's Hospital,Foshan 528500,Guangdong Province,China)

机构地区：[1]佛山市高明区人民医院急诊科,广东佛山528500 [2]佛山市高明区人民医院心内科,广东佛山528500

出　　处：《中外医药研究》2024年第33期33-35,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察血栓抽吸术联合不同剂量替罗非班对急性心肌梗死(AMI)患者的临床治疗效果。方法:选取佛山市高明区人民医院2023年1月—2024年2月收治的AMI且接受急诊经皮冠状动脉介入治疗的患者92例作为研究对象,采用随机数字表法将其分为观察组和对照组,各46例。在均使用血栓抽吸导管的基础上,对照组加用低剂量的替罗非班治疗,观察组加用高剂量替罗非班治疗。评估指标包括心肌灌注水平、心肌酶和心功能水平以及术后出血率。结果:较对照组而言,观察组ST段回落率、心肌梗死溶栓治疗血流3级比例较高,无复流率较低(P<0.05);较对照组而言,治疗后观察组肌酸激酶同工酶峰值、心肌肌钙蛋白T峰值、左心室舒张末期内径及左心室收缩末期内径水平降低,左室射血分数水平提高(P<0.05);较对照组而言,术后观察组出血率较低(P=0.036)。结论:应用高剂量替罗非班进行血栓抽吸术对改善急性心肌梗死后心脏灌注及心脏功能具有显著效果,且减少了术后出血风险。Objective:To observe the clinical effect of thrombus aspiration combined with different doses of tirofiban on patients with acute myocardial infarction(AMI).Methods:A total of ninety-two patients with AMI who received emergency percutaneous coronary intervention treatment in Foshan Gaofeng District People's Hospital from January 2023 to February 2024 were selected as the study objects,and were divided into observation group and control group by random number table method,with forty-six cases in each group.On the basis of using thrombus aspiration catheters,the control group was treated with low-dose tirofiban,while the observation group was treated with high-dose tirofiban.The evaluation measures included myocardial perfusion level,myocardial enzyme and cardiac function level,and postoperative bleeding rate.Results:Compared with the control group,the ST segment regression rate and the proportion of thrombolysis in myocardial infarction grade 3 were significantly higher in observa-tion group,and the rate of no reflow was lower(P<0.05);compared with control group,the peak value of creatine kinase isoenzyme,peak value of cardiac troponin T,left ventricular end-diastolic diameter and left ventricular end-systolic diameter in observation group were decreased after treatment,and left ventricular ejection fraction was increased(P<0.05);the bleeding rate of the obser-vation group was lower than that of the control group(P=0.036).Conclusion:Thrombus aspiration with high dose tirofiban has a significant effect on improving cardiac perfusion and cardiac function after acute myocardial infarction,and reduces the risk of postoperative bleeding.

关 键 词：血栓抽吸导管 替罗非班 急性心肌梗死 心肌酶 心功能 术后出血 

分 类 号：R542.22[医药卫生—心血管疾病]