五倍子汤联合地奥司明对肛瘘手术患者疼痛、创面愈合情况及肛门括约肌功能的影响  

Effects of Wubeizi Decoction Combined with Diosmin on Pain,Wound Healing Status and Anal Sphincter Function in Patients Undergoing Anal Fistula Surgery

作　　者：陈邦合 毛细云 王宏昌 李明月 CHEN Banghe;MAO Xiyun;WANG Hongchang;LI Mingyue(Dept.of Proctology,Anhui Provincial Hospital of Integrated Traditional Chinese and Western Medicine/Anhui Hospital of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Hefei 230000,China;Dept.of Proctology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine/Anhui Provincial Hospital of Traditional Chinese Medicine,Hefei 230000,China)

机构地区：[1]安徽省中西医结合医院/上海中医药大学附属曙光医院安徽医院肛肠科,合肥230000 [2]安徽中医药大学第一附属医院/安徽省中医院肛肠科,合肥230000

出　　处：《中国医院用药评价与分析》2024年第12期1469-1471,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：安徽省中医药传承创新科研项目(No.2020zcyb08);安徽中医药大学自然科学研究项目(No.2021sfylc17)。

摘　　要：目的:探讨五倍子汤联合地奥司明对肛瘘手术患者疼痛、创面愈合情况及肛门括约肌功能的影响。方法:选取2021年8月至2022年8月上海中医药大学附属曙光医院安徽医院收治的肛瘘手术患者106例,采用随机数字表法分为观察组(n=53)、对照组(n=53)。对照组患者给予地奥司明治疗,观察组患者在对照组的基础上联合五倍子汤治疗。比较两组肛瘘手术患者的临床疗效,治疗前后疼痛程度、创面愈合情况和肛门括约肌功能,以及不良反应发生情况。结果:观察组患者的总有效率为94.34%(50/53),高于对照组的73.58%(39/53),差异有统计学意义(P<0.05)。与对照组比较,观察组患者治疗后的疼痛视觉模拟评分降低,创面面积缩小,创面愈合率升高,Wexner评分降低,差异均有统计学意义(P<0.05)。观察组、对照组患者的总不良反应发生率分别为3.77%(2/53)、7.55%(4/53),差异无统计学意义(P>0.05)。结论:五倍子汤联合地奥司明用于肛瘘手术患者的疗效较好,可加快创面愈合及缓解疼痛,促进肛门括约肌功能恢复,且有较高的安全性。OBJECTIVE:To probe into the effects of Wubeizi decoction combined with diosmin on pain,wound healing status and anal sphincter function in patients undergoing anal fistula surgery.METHODS:A total of 106 patients undergoing anal fistula surgery from Aug.2021 to Aug.2022 in Anhui Hospital of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were selected to be divided into the observation group(53 cases)and control group(53 cases)via random number table.The control group was given diosmin,while the observation group received Wubeizi decoction based on the control group.The clinical efficacy,pain degree,wound healing status and anal sphincter function before and after treatment,and the incidences of adverse drug reactions were compared between two groups.RESULTS:The total effective rate of the observation group was 94.34%(50/53),higher than 73.58%(39/53)of the control group,with statistically significant difference(P<0.05).Compared with the control group,the observation group had lower visual analog score of pain,smaller wound area,higher wound healing rate and lower Wexner score after treatment,with statistically significant differences(P<0.05).The overall incidences of adverse drug reactions of the observation group and the control group were respectively 3.77%(2/53)and 7.55%(4/53),the difference was not statistically significant(P>0.05).CONCLUSIONS:The efficacy of Wubeizi decoction combined with diosmin for patients undergoing anal fistula surgery is remarkable,which can accelerate wound healing and relieve pain,promote the recovery of anal sphincter function,with high safety.

关 键 词：肛瘘 五倍子汤 地奥司明 疼痛 创面愈合情况 肛门括约肌功能 

分 类 号：R969.4[医药卫生—药理学] R932[医药卫生—药学]