基于决策树模型的一清胶囊治疗牙龈炎(热毒证)的药物经济学评价  

Pharmacoeconomics Evaluation on Yiqing Capsule in the Treatment of Gingivitis(Heat-Toxin Syndrome)Based on Decision Tree Model

作　　者：陈子佳 黄艳丽 崔鑫 韩晟[2] 王志飞[1] 谢雁鸣[1] CHEN Zijia;HUANG Yanli;CUI Xin;HAN Sheng;WANG Zhifei;XIE Yanming(Institute of Clinical Basic Medicine of Traditional Chinese Medicine,Chinese Academy of Traditional Chinese Medicine,Beijing 100010,China;International Research Center for Pharmaceutical Management,Peking University,Beijing 100089,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100010 [2]北京大学医药管理国际研究中心,北京100089

出　　处：《中国医院用药评价与分析》2024年第12期1490-1494,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家重点研发计划项目(No.2018YFC1707410);中国中医科学院科技创新工程重大攻关项目(No.CI2021A00702)。

摘　　要：目的:评价一清胶囊治疗牙龈炎(热毒证)的经济性,以期为卫生医疗资源的合理配置提供参考依据。方法:从卫生体系角度出发,基于文献筛选后的有效性循证医学证据,运用TreeAge Pro 2018.2.1软件构建模型,对一清胶囊治疗牙龈炎(热毒证)进行成本-效果分析和敏感性分析。模型的干预周期为7 d,成本参数源于药智网数据库和北京市医疗保障局官网,效果参数基于筛选出的1篇随机对照试验(RCT)报告的牙龈疼痛消失率。一清胶囊组的治疗方案为一清胶囊,对照组的治疗方案为牛黄解毒胶囊。结果:基础分析结果表明,以对照组方案为参照,一清胶囊组方案的增量成本为-119.70元,增量效果为15.10%,因此占有绝对优势。单因素敏感性分析显示,患者用药依从性对结果影响较大,除该因素外,一清胶囊组的效果参数对研究结果产生了重要影响。概率敏感性分析显示,基于该RCT研究的经济学中,一清胶囊组方案的经济性更高,并且与基础分析结果相一致。结论:与牛黄解毒胶囊比较,一清胶囊治疗牙龈炎(热毒证)患者更具经济性。OBJECTIVE:To evaluate the economical efficiency of Yiqing capsules in the treatment of gingivitis(heat-toxin syndrome),so as to provide reference for the rational allocation of healthcare resources.METHODS:From a health system perspective,TreeAge Pro 2018.2.1 software was used to construct a model to perform cost-effectiveness analysis and sensitivity analysis on Yiqing capsules for the treatment of gingivitis(heat-toxin syndrome)based on the evidence-based evidence of effectiveness after literature screening.The intervention period of the model was 7 d,the cost parameters were derived from the Yaozhi network database and the official website of Beijing Municipal Medical Insurance Bureau,and the effect parameters were based on the disappearance rate of gingival pain reported by a screened randomized controlled trial(RCT).The therapeutic regimen of Yiqing capsule group was Yicheng capsule,and that of the control group was Niuhuang Jiedu capsule.RESULTS:With the control group regimen as a reference,the results of fundamental analysis showed that the incremental cost of the Yiqing capsules group regimen was-119.70 RMB,which was approximately 2.16%of per capita disposable income in China(36883 RMB)in 2023.The single-factor sensitivity analysis showed that the effect parameters of Yiqing capsule group had a significant impact on the research results.In addition,the effective rate of Yiqing capsule group also had a significant impact on the research results.and the incremental effect was 15.10%,which was considered to have an absolute advantage.The single-factor sensitivity analysis indicated that patient medication adherence has a significant impact on the outcomes.In addition,the efficacy parameters of the Yiqing capsules group exerted a substantial influence on the research findings.Probabilistic sensitivity analysis showed that Yiqing capsule group regimen had higher economical efficiency based on the economics in this RCT,which was consistent with the results of fundamental analysis.CONCLUSIONS:Compared with Niuhu

关 键 词：一清胶囊 牙龈炎 热毒证 成本-效果分析 经济学评价 

分 类 号：R932[医药卫生—生药学]