奥法妥木单抗治疗高龄难治性抗代谢型谷氨酸受体5脑炎的药学监护  

Pharmaceutical Care for An Elderly Patient with mGluR5 Antibody Encephalitis Treated with Ofatumumab

作　　者：高玲娜 朱小丽 杜雪亭 韩敬哲 GAO Lingna;ZHU Xiaoli;DU Xueting;HAN Jingzhe(Department of Pharmacy,the People's Hospital of Hengshui,Hengshui 053000,China;Department of Neurology,the People's Hospital of Hengshui,Hengshui 053000,China)

机构地区：[1]衡水市人民医院药学部,衡水053000 [2]衡水市人民医院神经内科,衡水053000

出　　处：《医药导报》2025年第1期116-120,共5页Herald of Medicine

摘　　要：目的探讨临床药师参与奥法妥木单抗治疗高龄难治性抗代谢型谷氨酸受体5(mGluR5)脑炎患者的药学监护,为难治性自身免疫性脑炎(AE)患者的治疗和药学监护提供参考。方法一线免疫治疗效果不佳的抗mGluR5脑炎患者1例,81岁,临床药师结合患者病情及治疗药物特点确定药学监护要点,对奥法妥木单抗的选用、给药方式、药物相互作用、不良反应及注意事项等方面提出药学相关建议,同时对患者及其家属进行用药指导和出院教育,并对其进行定期随访。结果临床药师与医师相互配合,为患者提供全程药学服务,患者病情好转,随访情况良好。结论临床药师关注患者使用奥法妥木单抗治疗的有效性和安全性,开展全程个体化药学监护,取得了良好的效果。Objective To analyze the involvement of pharmacists in the pharmaceutical care of olfacatumumab in the treatment of elderly patients with refractory anti-metabotropic glutamate receptor 5(mGluR5)encephalitis and to provide a reference for the treatment and pharmaceutical care of patients with refractory autoimmune encephalitis(AE).Methods An 81-year-old patient with anti-mGluR5 encephalitis who had poor first-line immunotherapy effect.The key points of pharmaceutical care were determined according to the patient's condition and the characteristics of therapeutic drugs.The drug selection,administration mode,drug interaction,adverse reactions,and precautions of ofatumumab were put forward.At the same time,the patients and their families were given medication guidance and discharge education,and regular follow-up was carried out.Results With the cooperation of doctors,the patient was provided with whole-process pharmaceutical care,and the patient's condition was improved,and the patient's condition was good so far.Conclusion Clinical pharmacists pay attention to the effectiveness and safety of the treatment with ofatumumab by carrying out individualized pharmaceutical care for this patient,which fully reflects the value of clinical pharmacists and provides a reference for the treatment and pharmaceutical care of refractory AE patients.

关 键 词：奥法妥木单抗 抗代谢型谷氨酸受体5脑炎 高龄 药学监护 

分 类 号：R979.5[医药卫生—药品] R969.3[医药卫生—药学]