丙泊酚致过敏性休克死亡1例  

A Case of Anaphylactic Shock and Death Caused by Propofol

作　　者：李晓东 彭芳 杨丹 LI Xiaodong;PENG Fang;YANG Dan(Department of Pharmacy,the First People's Hospital of Anning City,Kunming 650300,China;Kunming Adverse Drug Reaction and Drug Abuse Monitoring Center,Kunming 650000,China)

机构地区：[1]安宁市第一人民医院药学部,昆明650300 [2]昆明市药品不良反应与药物滥用监测中心,昆明650000

出　　处：《医药导报》2025年第1期131-133,共3页Herald of Medicine

基　　金：昆明市卫生健康委员会卫生科研项目(2022-13-01-009)。

摘　　要：患者,女,48岁,因子宫内节育器取出手术麻醉给予丙泊酚乳状注射液100 mg,静脉注射,发生过敏性休克死亡。采用诺氏评分法判断怀疑药品致过敏性休克死亡相关性,结合相关文献分析丙泊酚导致过敏的作用机制,警戒临床关注丙泊酚的安全性,并为避免使用丙泊酚出现过敏性休克提出了可行建议。The patient,female,48 years old,died of anaphylactic shock due to anesthesia with an intravenous injection of 100 mg propofol emulsion injection in the removal surgery of the intrauterine device.We used the Norris scoring method to determine the association between suspected drug,anaphylactic shock,and death,combined with relevant literature analysis of the mechanism of propofol-induced allergy,to alert clinical attention to the safety of propofol.We proposed feasible suggestions to avoid the occurrence of anaphylactic shock caused by propofol.

关 键 词：丙泊酚 过敏性休克 死亡 药品不良反应 

分 类 号：R971[医药卫生—药品] R969.3[医药卫生—药学]